期刊
ISCIENCE
卷 25, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2022.104453
关键词
-
资金
- National Natural Science Foundation of China [31670937]
Neutrophils play a crucial role in immune responses, and it has been found that they can regulate antibody reactions induced by vaccines at immunization sites. Inhibiting BAFF in neutrophils can weaken B cell activation and antibody production.
Neutrophils played a key role in the innate immune responses. Less is known about whether and how the neutrophils recruited in the immunization sites affecting the vaccine-induced antibody responses. In the process of evaluating the efficacy of an oil-in-water emulsion- formulated vaccine in mice, we found that neutrophils were rapidly and massively recruited to immunization sites but were barely detected in the draining lymph nodes. Interestingly, B cell-activating factor (BAFF) was abundantly expressed in the recruiting neutrophils at a very early stage. The initial neutrophil-derived BAFF firstly brought about the B cell responses in the local part, then subsequently in lymphoid organs. Activated B cells produced more BAFF through TLR9-IRF5 signaling pathway, thereby amplifying the vaccine-induced antibody responses. Suppressing BAFF in the neutrophils could weaken the B cell activation and reduce the antibody production. The data indicate that vaccines endow neutrophils with the potential to orchestrate antibody responses at immunization sites.
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