Dynamics of intracellular clusters of nanoparticles

Article Mathematics

Stochastic Model of Virus-Endosome Fusion and Endosomal Escape of pH-Responsive Nanoparticles

Sergei Fedotov et al.

Summary: In this paper, a stochastic model is established to study the dynamics of active Rab5 and Rab7 proteins on the surface of endosomes and the acidification process affecting the escape of viruses and pH-responsive nanoparticles.

MATHEMATICS (2022)

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Review Pharmacology & Pharmacy

Nanoparticle Toxicology

Wen Yang et al.

Summary: This article reviews the potential adverse effects of nanoparticles on human health and discusses mechanisms of nanotoxicity, including the generation of reactive oxygen species, nanoparticle disintegration, and modulation of cell signaling pathways. Improved understanding of nanoparticle toxicity may lead to strategies for safe application of nanotechnology.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

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Review Chemistry, Multidisciplinary

Biomedical nanoparticle design: What we can learn from viruses

Sara Maslanka Figueroa et al.

Summary: Viruses, as nanomaterials, possess unique properties that allow for efficient infection of host cells and evasion of the immune system. While there have been efforts to mimic viral traits to improve nanomaterial performance, a comprehensive evaluation of the impact of virus-mimetic material design on the targeting efficiency of nanomaterials is currently lacking.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Oncology

A novel formulation of theranostic nanomedicine for targeting drug delivery to gastrointestinal tract cancer

Madeeha Shahzad Lodhi et al.

Summary: The study designed a novel targeted gold nanoparticle theranostic formulation for gastrointestinal cancers, which showed better therapeutic and prognostic effects compared to pure doxorubicin treatment in mice.

CANCER NANOTECHNOLOGY (2021)

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Article Oncology

Multi-scale Monte Carlo simulations of gold nanoparticle-induced DNA damages for kilovoltage X-ray irradiation in a xenograft mouse model using TOPAS-nBio

Alexander P. Klapproth et al.

Summary: The study utilized a multi-scale Monte Carlo simulation framework to investigate the biological mechanisms of AuNPs in increasing DNA damage in mouse tumor models. Results showed that AuFeNP induced enhancement of both dose and DNA strand breaks, with an increased production of chemical radicals responsible for DNA damage. The location of cells within the tumor for 200-kVp X-ray beams was found to have an impact on the results.

CANCER NANOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Fusion and fission events regulate endosome maturation and viral escape

Mario Castro et al.

Summary: Endosomes play a crucial role in mediating cell communication with the extracellular environment and regulating intracellular trafficking. Viruses can hijack endosomes to replicate and evade degradation, with endosomal maturation depending on Rab proteins. The relationship between endosomal active Rab levels and pH may contribute to variability in viral escape times and ultimately regulate the viability of a viral intracellular infection.

SCIENTIFIC REPORTS (2021)

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Article Oncology

On the Equivalence of the Biological Effect Induced by Irradiation of Clusters of Heavy Atom Nanoparticles and Homogeneous Heavy Atom-Water Mixtures

Balder Villagomez-Bernabe et al.

Summary: The study demonstrates the potential of using nanoparticles in radiotherapy to reduce the survival fraction of tumor cells and minimize damage to healthy cells. By comparing the effects of gold nanoparticle clusters and a water-gold mixture on cell damage, it was found that the difference between them is minor, simplifying the modeling of complex geometries of nanoparticle aggregations and saving computational resources.

CANCERS (2021)

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Article Physics, Multidisciplinary

Local Analysis of Heterogeneous Intracellular Transport: Slow and Fast Moving Endosomes

Nickolay Korabel et al.

Summary: Trajectories of endosomes inside living eukaryotic cells are complex and heterogeneous, with some displaying persistent and anti-persistent motion while others remain in one position. By analyzing slow and fast moving endosomes separately, researchers found that both types exhibit a spectrum of local anomalous exponents and local generalized diffusion coefficients. This suggests that heterogeneous fractional Brownian motion is an appropriate model for both fast and slow moving endosomes.

ENTROPY (2021)

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Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Sources of variability in nanoparticle uptake by cells

Christoffer Aberg et al.

Summary: The uptake of nanoparticles by cells is correlated with cell size within a cell population, but other cellular characteristics also contribute to cell-to-cell variability. These characteristics are more specific to the type of object being taken up, such as nanoparticles or proteins, complicating their detailed identification.

NANOSCALE (2021)

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Article Materials Science, Biomaterials

Enhancing the Anticancer Activity and Selectivity of Goniothalamin Using pH-Sensitive Acetalated Dextran (Ac-Dex) Nanoparticles: A Promising Platform for Delivery of Natural Compounds

Carolyne B. Braga et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Multidisciplinary Sciences

The shape of dendritic tips

Dmitri V. Alexandrov et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2020)

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Article Pharmacology & Pharmacy

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

Vladimir Panov et al.

DOSE-RESPONSE (2020)

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Article Chemistry, Physical

Nuclear Uptake of Gold Nanoparticles Deduced Using Dual-Angle X-Ray Fluorescence Mapping

Aaron McCulloch et al.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2019)

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Article Multidisciplinary Sciences

The origin of heterogeneous nanoparticle uptake by cells

Paul Rees et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Physical Radiation Enhancement Effects Around Clinically Relevant Clusters of Nanoagents in Biological Systems

B. Villagomez-Bernabe et al.

SCIENTIFIC REPORTS (2019)

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Article Chemistry, Multidisciplinary

A Virus-Mimicking pH-Responsive Acetalated Dextran-Based Membrane-Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics

Saowanee Wannasarit et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Computer Science, Interdisciplinary Applications

A new iterative scheme for solving the discrete Smoluchowski equation

Alastair J. Smith et al.

JOURNAL OF COMPUTATIONAL PHYSICS (2018)

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Review Nanoscience & Nanotechnology

Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties

Alyona Sukhanova et al.

NANOSCALE RESEARCH LETTERS (2018)

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Review Radiology, Nuclear Medicine & Medical Imaging

Metallic nanoparticle radiosensitisation of ion radiotherapy: A review

Dylan Peukert et al.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2018)

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Review Nanoscience & Nanotechnology

Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties

Alyona Sukhanova et al.

NANOSCALE RESEARCH LETTERS (2018)

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Review Biochemistry & Molecular Biology

Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications

Fen-Ying Kong et al.

MOLECULES (2017)

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Article Chemistry, Multidisciplinary

Dependence of gold nanoparticle radiosensitization on cell geometry

Wonmo Sung et al.

NANOSCALE (2017)

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Article Multidisciplinary Sciences

Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging

Mengmeng Liu et al.

NATURE COMMUNICATIONS (2017)

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Review Nanoscience & Nanotechnology

Towards clinically translatable in vivo nanodiagnostics

Seung-min Park et al.

NATURE REVIEWS MATERIALS (2017)

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Review Pharmacology & Pharmacy

Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements

Sohyoung Her et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

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Article Biochemical Research Methods

Evolution of gold nanoparticle clusters in living cells studied by sectional dark-field optical microscopy and chromatic analysis

Sheng-Hann Wang et al.

JOURNAL OF BIOPHOTONICS (2016)

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Article Engineering, Biomedical

Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy

Yuting Lin et al.

PHYSICS IN MEDICINE AND BIOLOGY (2015)

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Article Materials Science, Multidisciplinary

Gold Nanoparticle Uptake in Whole Cells in Liquid Examined by Environmental Scanning Electron Microscopy

Diana B. Peckys et al.

MICROSCOPY AND MICROANALYSIS (2014)

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Review Pharmacology & Pharmacy

Toxicology of nanoparticles

Andreas Elsaesser et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Article Biochemistry & Molecular Biology

A General Theoretical Framework to Infer Endosomal Network Dynamics from Quantitative Image Analysis

Lionel Foret et al.

CURRENT BIOLOGY (2012)

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Article Chemistry, Multidisciplinary

Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

Kejin Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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Article Chemistry, Multidisciplinary

Visualizing Gold Nanoparticle Uptake in Live Cells with Liquid Scanning Transmission Electron Microscopy

Diana B. Peckys et al.

NANO LETTERS (2011)

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Article Chemistry, Multidisciplinary

Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation

Evaldas Sadauskas et al.

CHEMISTRY CENTRAL JOURNAL (2009)

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Review Biotechnology & Applied Microbiology

Knocking down barriers: advances in siRNA delivery

Kathryn A. Whitehead et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

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Review Pharmacology & Pharmacy

Gold nanoparticles in delivery applications

Partha Ghosh et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

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Article Engineering, Biomedical

The use of gold nanoparticles to enhance radiotherapy in mice

JF Hainfeld et al.

PHYSICS IN MEDICINE AND BIOLOGY (2004)

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Dynamics of intracellular clusters of nanoparticles

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