4.5 Article

Dynamics of intracellular clusters of nanoparticles

期刊

CANCER NANOTECHNOLOGY
卷 13, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12645-022-00118-x

关键词

Nanoparticles; Clusters; Endosomes; Smoluchowski's equation

资金

  1. EPSRC [EP/V008641/1]
  2. Russian Science Foundation [20-61-46013]

向作者/读者索取更多资源

Nanoparticles play a crucial role in cancer treatment and drug delivery. This study obtained the cluster density of nanoparticles using Smoluchowski's coagulation equation and compared it with experimental data. The results show that the exact cluster density provides a better description of nanoparticle distribution inside cells.
Background: Nanoparticles play a crucial role in nanodiagnostics, radiation therapy of cancer, and they are now widely used to effectively deliver drugs to specific sites, targeting whole organs and down to single cells, in a controlled manner. Therapeutic efficiency of nanoparticles greatly depends on their clustering distribution inside cells. Our purpose is to find the cluster density using Smoluchowski's coagulation equation with injections. Results: We obtain an exact cluster density of nanoparticles as the steady-state solution of Smoluchowski's equation describing clustering due to the fusion of endosomes. We also analyze the unsteady cluster distribution and compare it with the experimental data for time evolution of gold nanoparticle clusters in living cells. Conclusions: We show the steady cluster density is in good agreement with experimental data on gold nanoparticle distribution inside endosomes. We find that for clusters containing between 1 and 20 nanoparticles, the exact cluster density provides a better description of the existing experimental data than the well-known approximate asymptotic power-law distribution x(-3/2)

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据