4.7 Article

Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer's Disease: A Review

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease

Melania Gonzalez-Rodriguez et al.

Summary: This study assessed hippocampal atrophy and/or gliosis in Alzheimer's disease using quantification and proteomic analysis. The results showed reduced hippocampal volume, particularly in the CA1 region, which correlated with neuronal loss and astrogliosis. The study also identified downregulated and upregulated proteins related to neurodegeneration and gliosis, including Hsp90 family chaperones possibly involved in degrading A beta and tau through chaperone-mediated autophagy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Neurosciences

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

Giovanni B. Frisoni et al.

Summary: The amyloid hypothesis has long been the leading model for the pathogenesis of Alzheimer's disease, but a probabilistic model is proposed as an alternative due to the increasing understanding of the complex biology of Alzheimer's disease. This new model suggests that genetic factors, environmental exposures, and lower-risk genes play significant roles in different types of Alzheimer's disease, leading to a better understanding of disease pathophysiology and potentially accelerating the development of prevention and treatment strategies.

NATURE REVIEWS NEUROSCIENCE (2022)

Article Plant Sciences

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

Sravan Gopalkrishnashetty Sreenivasmurthy et al.

Summary: The study found that protopine (PRO) reduces abnormal tau protein in the brains of Alzheimer's disease (AD) patients, improving memory and cognition. The research confirmed the pharmacokinetics of PRO and its mechanism of action through experiments.

PHYTOMEDICINE (2022)

Article Clinical Neurology

Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease

Stephen Salloway et al.

Summary: The EMERGE and ENGAGE phase 3 trials provided data on ARIA associated with aducanumab treatment in patients with Alzheimer's disease. A high rate of ARIA was observed, with ARIA-edema being the most common adverse event. Some patients in the aducanumab group experienced associated symptoms, with headache being the most common.

JAMA NEUROLOGY (2022)

Article Chemistry, Multidisciplinary

TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2

Chuan-bin Yang et al.

Summary: The study reveals that TFEB, a key regulator of autophagy and lysosomal biogenesis, can promote cell apoptosis in response to 15d-PGJ2 through ROS-mediated translocation into the nucleus and subsequent upregulation of ATF4. This novel role of TFEB in apoptosis induction provides new insights into the complex mechanisms underlying cellular responses to 15d-PGJ2.

ACTA PHARMACOLOGICA SINICA (2022)

Article Cell Biology

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Benjamin Chun-Kit Tong et al.

Summary: This study identified a mechanism of impairment in the macroautophagy/autophagy-lysosomal pathway (ALP) in Alzheimer's disease, mediated by the lysosomal TPCN2/TPC2 channel. Targeting TPCN2 was shown to restore lysosomal function and reduce amyloid plaque accumulation, suggesting a potential therapeutic strategy for AD treatment in the future.

AUTOPHAGY (2022)

Article Cell Biology

Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease

Wei Zhang et al.

Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with limited effective therapeutics. Autophagy plays a crucial role in AD progression, and enhancing autophagy pathway is a potential strategy to degrade pathological proteins. Celastrol, a natural small molecule, has been found to activate autophagy and improve memory deficits in AD animal models, suggesting it as a novel drug candidate for AD and other tauopathies.

AUTOPHAGY (2022)

Article Immunology

Mechanism of the Fibroblast Growth Factor 23/α-Klotho Axis in Peripheral Blood Mononuclear Cell Inflammation in Alzheimer's Disease

Baoshan Li et al.

Summary: This study investigated the role of the FGF23/alpha-Klotho axis in Alzheimer's disease, finding that AD patients had increased FGF23 protein concentration and reduced alpha-Klotho protein concentration, which correlated with levels of inflammatory cytokines. Inhibiting FGF23 or overexpressing alpha-Klotho decreased production of inflammatory cytokines and activated the Wnt/beta-catenin pathway in AD-PBMCs, showing that the FGF23/alpha-Klotho axis can regulate AD-induced cell inflammation through the Wnt/beta-catenin pathway.

IMMUNOLOGICAL INVESTIGATIONS (2022)

Review Biochemistry & Molecular Biology

Alzheimer's Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration

Siva Sundara Kumar Durairajan et al.

Summary: Alzheimer's disease affects over 50 million people worldwide and is characterized by the presence of Aβ plaques and hyperphosphorylated Tau in the brain. Recent clinical trials targeting Aβ have been unsuccessful, indicating the need for alternative targets such as Tau. Drug discovery approaches for AD-related Tau pathologies primarily focus on blocking aggregation, inhibiting phosphorylation, compensating impaired function, and targeting degradation pathways. Currently available Tau-directed drugs have limitations, warranting further studies.

CURRENT MOLECULAR PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer's disease mouse model

Roy Chun-Laam Ng et al.

Summary: The decrease in circulating adiponectin levels is associated with neurodegeneration, neuroinflammation, and Alzheimer's disease pathologies. Increasing adiponectin through treatments like adipoRon can improve neuronal insulin signaling, memory functions, and reduce amyloid levels in Alzheimer's disease models.

MOLECULAR PSYCHIATRY (2021)

Review Medicine, Research & Experimental

Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review

Zi-Ying Wang et al.

Summary: Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system, with autophagy playing a key role in the neurodegeneration process. Traditional Chinese medicine (TCM) regulating autophagy shows potential as a therapy for NDs.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Biochemistry & Molecular Biology

Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy

Marlena Typiak et al.

Summary: Klotho, initially introduced as an antiaging molecule, plays a crucial role in regulating phosphate and calcium metabolism, protecting against oxidative stress, and downregulating apoptosis. Despite its beneficial effects in diabetes and diabetic nephropathy, the therapeutic potential of Klotho is reduced in early stages of inflammation due to downregulation by proinflammatory factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Plant Sciences

Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease

Ashok Iyaswamy et al.

Summary: The study demonstrated that QYS extract improved cognitive function and attenuated AD pathology in 3XTg mice by promoting the expression of PPAR alpha and TFEB, and enhancing ALP both in vivo and in vitro.

PHYTOMEDICINE (2021)

Review Biochemistry & Molecular Biology

The Role of the Inflammasome in Neurodegenerative Diseases

Federica Piancone et al.

Summary: Neurodegenerative diseases are chronic, progressive disorders characterized by inflammation in the central nervous system. Various conditions seem to share a common inflammatory mechanism.

MOLECULES (2021)

Article Chemistry, Analytical

Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation

Xueli Wang et al.

Summary: Novel near infrared emissive fluorophores exhibit strong selectivity towards Aβ oligomers and monomers, good biocompatibility and stability, and significant inhibitory effects on Aβ aggregation.

TALANTA (2021)

Review Cardiac & Cardiovascular Systems

Shedding of Klotho: Functional Implications in Chronic Kidney Disease and Associated Vascular Disease

Valeria Saar-Kovrov et al.

Summary: Alpha-Klotho exists in membrane-bound and soluble forms, with soluble Klotho arising exclusively from shedding. Reduced levels of soluble Klotho are associated with chronic kidney disease (CKD) and its cardiovascular complications. The exact mechanisms and functional implications of soluble Klotho in CKD and vascular function remain to be fully elucidated.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Review Pharmacology & Pharmacy

Resveratrol in Rodent Models of Parkinson's Disease: A Systematic Review of Experimental Studies

Cheng-Fu Su et al.

Summary: Parkinson's disease (PD) is a common neurodegenerative disease characterized by the progressive degeneration of nigrostriatal dopaminergic neurons and motor function impairment. Resveratrol, a polyphenol found in plants and fruits, has shown potent neuroprotective efficacy in various PD animal models through antioxidation, anti-inflammation, ameliorating mitochondrial dysfunction, and improving motor function. The systematic analysis of 18 studies reveals significant neuroprotective effects of resveratrol on PD models and highlights the importance of methodological quality assessment in preclinical research.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

Gisele Pereira Dias et al.

Summary: The study showed that intermittent fasting improves long-term memory retention, increases neurogenesis in the hippocampus, and enhances cognition by upregulating the longevity gene Klotho, particularly through enhancing adult hippocampal neurogenesis.

MOLECULAR PSYCHIATRY (2021)

Article Multidisciplinary Sciences

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease

Julia Neitzel et al.

Summary: The Klotho-VS haplotype is associated with reduced risk of Alzheimer's disease and dementia. This study demonstrates an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data. KL-VShet carriers show lower levels of tau-PET per unit increase in amyloid-PET, suggesting a protective role against amyloid-related tau pathology and memory impairments in elderly individuals at risk of AD dementia.

NATURE COMMUNICATIONS (2021)

Review Pharmacology & Pharmacy

Klotho as Potential Autophagy Regulator and Therapeutic Target

Hongjing Zhou et al.

Summary: Klotho protein can delay aging and is associated with various aging-related diseases. By increasing Klotho expression, therapeutic effects can be achieved for these diseases, as Klotho plays a role in regulating the autophagic process.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

Daniela Hartl et al.

MOLECULAR PSYCHIATRY (2020)

Article Food Science & Technology

NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models

Ashok Iyaswamy et al.

JOURNAL OF FOOD AND DRUG ANALYSIS (2020)

Review Cell Biology

Targeting Aggrephagy for the Treatment of Alzheimer's Disease

Sandeep Malampati et al.

Review Biochemistry & Molecular Biology

The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases

Ralph A. Nixon

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)

Review Clinical Neurology

New Insights Into the Pathogenesis of Alzheimer's Disease

Liyuan Fan et al.

FRONTIERS IN NEUROLOGY (2020)

Article Endocrinology & Metabolism

IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER

Xiao-Wen Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

Review Endocrinology & Metabolism

Klotho, Aging, and the Failing Kidney

Sarah Buchanan et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Endocrinology & Metabolism

Plasma Soluble alpha Klotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults

Michelle Shardell et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2020)

Review Neurosciences

Klotho at the Edge of Alzheimer's Disease and Senile Depression

Giulia Paroni et al.

MOLECULAR NEUROBIOLOGY (2019)

Review Biochemistry & Molecular Biology

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease

Zhou Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Neurosciences

Insulin and Autophagy in Neurodegeneration

Natalia Prudente de Mollo et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Cell Biology

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

Chiara Di Malta et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Oncology

The Emerging Roles of mTORC1 in Macromanaging Autophagy

Akpedje S. Dossou et al.

CANCERS (2019)

Article Genetics & Heredity

Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension

Kai Chen et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2019)

Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

Review Cell Biology

Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy

Kang Luo et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Biochemistry & Molecular Biology

Effect of Klotho on autophagy clearance in tacrolimus-induced renal injury

Sun Woo Lim et al.

FASEB JOURNAL (2019)

Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Geriatrics & Gerontology

Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications

Md. Sahab Uddin et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Review Neurosciences

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia

Liying Yang et al.

FRONTIERS IN NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

Alvaro F. Fernandez et al.

NATURE (2018)

Review Clinical Neurology

Klotho protein in neurodegenerative disorders

Magdalena Torbus-Paluszczak et al.

NEUROLOGICAL SCIENCES (2018)

Article Multidisciplinary Sciences

Klotho controls the brain-immune system interface in the choroid plexus

Lei Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Biotechnology & Applied Microbiology

The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases

Agnieszka Olejnik et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Review Medicine, Research & Experimental

Microglia in Alzheimer's disease

Heela Sarlus et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Clinical Neurology

Alzheimer's Disease: Past, Present, and Future

Mark W. Bondi et al.

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2017)

Article Multidisciplinary Sciences

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Carmen Venegas et al.

NATURE (2017)

Article Multidisciplinary Sciences

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Rhianna C. Laker et al.

NATURE COMMUNICATIONS (2017)

Review Immunology

The Role of Interferons in Inflammation and Inflammasome Activation

Natasa Kopitar-Jerala

FRONTIERS IN IMMUNOLOGY (2017)

Review Pharmacology & Pharmacy

Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies

Rik Mencke et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Review Cell Biology

Structure and function of the ULK1 complex in autophagy

Mary G. Lin et al.

CURRENT OPINION IN CELL BIOLOGY (2016)

Article Neurosciences

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease

Marina Saresella et al.

MOLECULAR NEURODEGENERATION (2016)

Article Physiology

Shedding of klotho by ADAMs in the kidney

Ellen P. M. van Loon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)

Article Neurosciences

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease

Richard D. Semba et al.

NEUROSCIENCE LETTERS (2014)

Review Biotechnology & Applied Microbiology

Behavioral and Psychological Symptoms in Alzheimer's Disease

Xiao-Ling Li et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Cell Biology

The ULK1 complex Sensing nutrient signals for autophagy activation

Pui-Mun Wong et al.

AUTOPHAGY (2013)

Editorial Material Cell Biology

Love and death: microglia, NLRP3 and the Alzheimer's brain

Tobias Goldmann et al.

CELL RESEARCH (2013)

Article Neurosciences

Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

Takahisa Kanekiyo et al.

JOURNAL OF NEUROSCIENCE (2013)

Review Biochemistry & Molecular Biology

Significance of the anti-aging protein Klotho

Miribane Dermaku-Sopjani et al.

MOLECULAR MEMBRANE BIOLOGY (2013)

Review Neurosciences

The NLRP3 Inflammasome in Alzheimer's Disease

Meng-Shan Tan et al.

MOLECULAR NEUROBIOLOGY (2013)

Article Multidisciplinary Sciences

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka et al.

NATURE (2013)

Review Biochemistry & Molecular Biology

The role of autophagy in neurodegenerative disease

Ralph A. Nixon

NATURE MEDICINE (2013)

Article Immunology

The NLRP3/ASC/Caspase-1 axis regulates IL-1ß processing in neutrophils

Arun K. Mankan et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

Michela Palmieri et al.

HUMAN MOLECULAR GENETICS (2011)

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Article Multidisciplinary Sciences

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre et al.

SCIENCE (2011)

Article Medicine, General & Internal

Klotho and the Aging Process

Makoto Kuro-o

KOREAN JOURNAL OF INTERNAL MEDICINE (2011)

Article Biotechnology & Applied Microbiology

Tumor Necrosis Factor-a Signaling in Macrophages

Narayanan Parameswaran et al.

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2010)

Review Biochemistry & Molecular Biology

mTOR regulation of autophagy

Chang Hwa Jung et al.

FEBS LETTERS (2010)

Article Neurosciences

Increased ATP-Binding Cassette Transporter A1 Expression in Alzheimer's Disease Hippocampal Neurons

Woojin Scott Kim et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Review Urology & Nephrology

Regulation of ion channels by secreted Klotho: mechanisms and implications

Chou-Long Huang

KIDNEY INTERNATIONAL (2010)

Article Biochemistry & Molecular Biology

ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Ian G. Ganley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Psychiatry

Neurobiology ofAlzheimer′s disease

E Mohandas et al.

Indian Journal of Psychiatry (2009)

Article Biochemistry & Molecular Biology

Hypervitaminosis D and premature aging:: lessons learned from Fgf23 and Klotho mutant mice

Mohammed S. Razzaque et al.

TRENDS IN MOLECULAR MEDICINE (2006)

Article Immunology

Interleukin-1 mediates Alzheimer and Lewy body pathologies

W. Sue T. Griffin et al.

JOURNAL OF NEUROINFLAMMATION (2006)

Review Endocrinology & Metabolism

Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin-in aging

A Bartke

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)

Article Gastroenterology & Hepatology

1α,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone:: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport

OI Kolek et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)

Article Biochemistry & Molecular Biology

Regulation of oxidative stress by the anti-aging hormone Klotho

M Yamamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Suppression of aging in mice by the hormone Klotho

H Kurosu et al.

SCIENCE (2005)