相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease
Melania Gonzalez-Rodriguez et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
Giovanni B. Frisoni et al.
NATURE REVIEWS NEUROSCIENCE (2022)
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition
Sravan Gopalkrishnashetty Sreenivasmurthy et al.
PHYTOMEDICINE (2022)
Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models
Cui-Zan Cai et al.
Theranostics (2022)
Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease
Stephen Salloway et al.
JAMA NEUROLOGY (2022)
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2
Chuan-bin Yang et al.
ACTA PHARMACOLOGICA SINICA (2022)
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease
Benjamin Chun-Kit Tong et al.
AUTOPHAGY (2022)
Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease
Wei Zhang et al.
AUTOPHAGY (2022)
Mechanism of the Fibroblast Growth Factor 23/α-Klotho Axis in Peripheral Blood Mononuclear Cell Inflammation in Alzheimer's Disease
Baoshan Li et al.
IMMUNOLOGICAL INVESTIGATIONS (2022)
Alzheimer's Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration
Siva Sundara Kumar Durairajan et al.
CURRENT MOLECULAR PHARMACOLOGY (2022)
Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer's disease mouse model
Roy Chun-Laam Ng et al.
MOLECULAR PSYCHIATRY (2021)
Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review
Zi-Ying Wang et al.
BIOMEDICINE & PHARMACOTHERAPY (2021)
Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
Marlena Typiak et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease
Ashok Iyaswamy et al.
PHYTOMEDICINE (2021)
The Role of the Inflammasome in Neurodegenerative Diseases
Federica Piancone et al.
MOLECULES (2021)
Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation
Xueli Wang et al.
TALANTA (2021)
Shedding of Klotho: Functional Implications in Chronic Kidney Disease and Associated Vascular Disease
Valeria Saar-Kovrov et al.
FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)
Resveratrol in Rodent Models of Parkinson's Disease: A Systematic Review of Experimental Studies
Cheng-Fu Su et al.
FRONTIERS IN PHARMACOLOGY (2021)
Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho
Gisele Pereira Dias et al.
MOLECULAR PSYCHIATRY (2021)
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease
Julia Neitzel et al.
NATURE COMMUNICATIONS (2021)
Klotho as Potential Autophagy Regulator and Therapeutic Target
Hongjing Zhou et al.
FRONTIERS IN PHARMACOLOGY (2021)
A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease
Daniela Hartl et al.
MOLECULAR PSYCHIATRY (2020)
Klotho-mediated changes in the expression of Atg13 alter formation of ULK1 complex and thus initiation of ER- and Golgi-stress response mediated autophagy
Jennifer Mytych et al.
APOPTOSIS (2020)
NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models
Ashok Iyaswamy et al.
JOURNAL OF FOOD AND DRUG ANALYSIS (2020)
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models
Ju-Xian Song et al.
AGING CELL (2020)
Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes
Jennifer Mytych et al.
CELLS (2020)
Targeting Aggrephagy for the Treatment of Alzheimer's Disease
Sandeep Malampati et al.
CELLS (2020)
The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases
Ralph A. Nixon
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)
New Insights Into the Pathogenesis of Alzheimer's Disease
Liyuan Fan et al.
FRONTIERS IN NEUROLOGY (2020)
A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38
Chuanbin Yang et al.
REDOX BIOLOGY (2020)
Klotho rewires cellular metabolism of breast cancer cells through alteration of calcium shuttling and mitochondrial activity
Riva Shmulevich et al.
ONCOGENE (2020)
Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases
Weihuang Zhang et al.
CELL DEATH DISCOVERY (2020)
The PI3K/AKT/mTOR pathway regulates autophagy to induce apoptosis of alveolar epithelial cells in chronic obstructive pulmonary disease caused by PM2.5 particulate matter
Fang Zhang et al.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)
Klotho overexpression improves amyloid-beta clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease
Yue Zhao et al.
AGING CELL (2020)
IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER
Xiao-Wen Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)
Klotho, Aging, and the Failing Kidney
Sarah Buchanan et al.
FRONTIERS IN ENDOCRINOLOGY (2020)
Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway
Jie Xu et al.
CHINESE MEDICINE (2020)
Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease
A. Iyaswamy et al.
FRONTIERS IN PHARMACOLOGY (2020)
Plasma Soluble alpha Klotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults
Michelle Shardell et al.
JOURNAL OF THE ENDOCRINE SOCIETY (2020)
Klotho at the Edge of Alzheimer's Disease and Senile Depression
Giulia Paroni et al.
MOLECULAR NEUROBIOLOGY (2019)
Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease
Zhou Zhu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Klotho-Mediated Changes in Shelterin Complex Promote Cytotoxic Autophagy and Apoptosis in Amitriptyline-Treated Hippocampal Neuronal Cells
Jennifer Mytych et al.
MOLECULAR NEUROBIOLOGY (2019)
Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice
Dongxue Li et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Insulin and Autophagy in Neurodegeneration
Natalia Prudente de Mollo et al.
FRONTIERS IN NEUROSCIENCE (2019)
Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice
Chen-Ye Zeng et al.
NEUROBIOLOGY OF AGING (2019)
Transcriptional Regulation of Autophagy: Mechanisms and Diseases
Chiara Di Malta et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)
The Emerging Roles of mTORC1 in Macromanaging Autophagy
Akpedje S. Dossou et al.
CANCERS (2019)
Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension
Kai Chen et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2019)
NLRP3 inflammasome activation drives tau pathology
Christina Ising et al.
NATURE (2019)
Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy
Kang Luo et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)
Klotho modulates ER-mediated signaling crosstalk between prosurvival autophagy and apoptotic cell death during LPS challenge
Jennifer Mytych et al.
APOPTOSIS (2019)
Effect of Klotho on autophagy clearance in tacrolimus-induced renal injury
Sun Woo Lim et al.
FASEB JOURNAL (2019)
p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1
Yingli He et al.
JOURNAL OF CELL BIOLOGY (2018)
Microglia in Alzheimer's disease
David V. Hansen et al.
JOURNAL OF CELL BIOLOGY (2018)
NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease
Jun Yin et al.
MOLECULAR NEUROBIOLOGY (2018)
Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease
Christian Lerch et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2018)
Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration
Christina Ising et al.
CELL DEATH & DISEASE (2018)
Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications
Md. Sahab Uddin et al.
FRONTIERS IN AGING NEUROSCIENCE (2018)
The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia
Liying Yang et al.
FRONTIERS IN NEUROSCIENCE (2018)
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice
Alvaro F. Fernandez et al.
NATURE (2018)
Klotho protein in neurodegenerative disorders
Magdalena Torbus-Paluszczak et al.
NEUROLOGICAL SCIENCES (2018)
Klotho controls the brain-immune system interface in the choroid plexus
Lei Zhu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases
Agnieszka Olejnik et al.
BIOMED RESEARCH INTERNATIONAL (2018)
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
Lionel B. Ivashkiv
NATURE REVIEWS IMMUNOLOGY (2018)
Microglia in Alzheimer's disease
Heela Sarlus et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Alzheimer's Disease: Past, Present, and Future
Mark W. Bondi et al.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2017)
Insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K/Akt/mTOR signaling pathway
Qi Liu et al.
MOLECULAR MEDICINE REPORTS (2017)
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease
Carmen Venegas et al.
NATURE (2017)
Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
Rhianna C. Laker et al.
NATURE COMMUNICATIONS (2017)
Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer's Disease
Xi Kuang et al.
FRONTIERS IN AGING NEUROSCIENCE (2017)
Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors
Sayad Kocahan et al.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE (2017)
The Role of Interferons in Inflammation and Inflammasome Activation
Natasa Kopitar-Jerala
FRONTIERS IN IMMUNOLOGY (2017)
NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models
Chuanbin Yang et al.
AUTOPHAGY (2017)
Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies
Rik Mencke et al.
ADVANCED DRUG DELIVERY REVIEWS (2017)
The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster
Ozlem Altintas et al.
BMB REPORTS (2016)
Structure and function of the ULK1 complex in autophagy
Mary G. Lin et al.
CURRENT OPINION IN CELL BIOLOGY (2016)
Antiaging Gene Klotho Deficiency Promoted High-Fat Diet-Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase
Yi Lin et al.
HYPERTENSION (2016)
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease
Marina Saresella et al.
MOLECULAR NEURODEGENERATION (2016)
Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
Dena B. Dubal et al.
JOURNAL OF NEUROSCIENCE (2015)
Shedding of klotho by ADAMs in the kidney
Ellen P. M. van Loon et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
David Heras-Sandoval et al.
CELLULAR SIGNALLING (2014)
Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model
Xi Kuang et al.
NEUROBIOLOGY OF AGING (2014)
Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease
Richard D. Semba et al.
NEUROSCIENCE LETTERS (2014)
Behavioral and Psychological Symptoms in Alzheimer's Disease
Xiao-Ling Li et al.
BIOMED RESEARCH INTERNATIONAL (2014)
The ULK1 complex Sensing nutrient signals for autophagy activation
Pui-Mun Wong et al.
AUTOPHAGY (2013)
Love and death: microglia, NLRP3 and the Alzheimer's brain
Tobias Goldmann et al.
CELL RESEARCH (2013)
Genetic Deficiency of Anti-Aging Gene Klotho Exacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice
Yi Lin et al.
ENDOCRINOLOGY (2013)
Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
Takahisa Kanekiyo et al.
JOURNAL OF NEUROSCIENCE (2013)
Significance of the anti-aging protein Klotho
Miribane Dermaku-Sopjani et al.
MOLECULAR MEMBRANE BIOLOGY (2013)
The NLRP3 Inflammasome in Alzheimer's Disease
Meng-Shan Tan et al.
MOLECULAR NEUROBIOLOGY (2013)
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
Michael T. Heneka et al.
NATURE (2013)
PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases
Mathea Pietri et al.
NATURE MEDICINE (2013)
The role of autophagy in neurodegenerative disease
Ralph A. Nixon
NATURE MEDICINE (2013)
The NLRP3/ASC/Caspase-1 axis regulates IL-1ß processing in neutrophils
Arun K. Mankan et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
Alzheimer's disease is not brain aging: neuropathological, genetic, and epidemiological human studies
Peter T. Nelson et al.
ACTA NEUROPATHOLOGICA (2011)
PTH Ablation Ameliorates the Anomalies of Fgf23-Deficient Mice by Suppressing the Elevated Vitamin D and Calcium Levels
Quan Yuan et al.
ENDOCRINOLOGY (2011)
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
Michela Palmieri et al.
HUMAN MOLECULAR GENETICS (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
Klotho and the Aging Process
Makoto Kuro-o
KOREAN JOURNAL OF INTERNAL MEDICINE (2011)
Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans
Marie-Therese Chateau et al.
AGING-US (2010)
Tumor Necrosis Factor-a Signaling in Macrophages
Narayanan Parameswaran et al.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2010)
mTOR regulation of autophagy
Chang Hwa Jung et al.
FEBS LETTERS (2010)
Increased ATP-Binding Cassette Transporter A1 Expression in Alzheimer's Disease Hippocampal Neurons
Woojin Scott Kim et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Regulation of ion channels by secreted Klotho: mechanisms and implications
Chou-Long Huang
KIDNEY INTERNATIONAL (2010)
Clearance of Amyloid-beta Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimer's Disease
R. Deane et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2009)
ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
Ian G. Ganley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Neuronal protein trafficking associated with Alzheimer disease From APP and BACE1 to glutamate receptors
Bor Luen Tang
CELL ADHESION & MIGRATION (2009)
Neurobiology ofAlzheimer′s disease
E Mohandas et al.
Indian Journal of Psychiatry (2009)
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Annett Halle et al.
NATURE IMMUNOLOGY (2008)
Hypervitaminosis D and premature aging:: lessons learned from Fgf23 and Klotho mutant mice
Mohammed S. Razzaque et al.
TRENDS IN MOLECULAR MEDICINE (2006)
Interleukin-1 mediates Alzheimer and Lewy body pathologies
W. Sue T. Griffin et al.
JOURNAL OF NEUROINFLAMMATION (2006)
Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin-in aging
A Bartke
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)
1α,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone:: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport
OI Kolek et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
Regulation of oxidative stress by the anti-aging hormone Klotho
M Yamamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Suppression of aging in mice by the hormone Klotho
H Kurosu et al.
SCIENCE (2005)