期刊
BIOMEDICINES
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10051054
关键词
personal care product; endocrine-disrupting chemical; pregnant women; preeclampsia; gestational hypertension
资金
- Foundation for Science and Technology (FCT)
- European Regional Development Fund (ERDF), under the Portugal 2020 Program, through the Regional Operational Program of the Center (Centro2020) [UIDB/00709/2020+UIDP/00709/2020]
- FCT [2020.06616.BD]
- national funds (OE), through FCT-Fundacao para a Ciencia e a Tecnologia, I.p.
- FCT/MCTES [UIDP/50017/2020+UIDB/50017/2020+ LA/P/0094/2020]
- Fundação para a Ciência e a Tecnologia [2020.06616.BD] Funding Source: FCT
Everyday use of personal care products containing UV filters can have toxic effects on human health due to the presence of endocrine-disrupting chemicals (EDCs). This study investigated the long-term effects of exposure to octylmethoxycinnamate (OMC), the most widely used UV-B filter, on vascular homeostasis. The findings suggested that OMC exposure increased the reactivity of human umbilical artery (HUA) to contractile agents, which may be a precursor to the development of preeclampsia and gestational hypertension.
Every day, people use personal care products containing UV filters. Although their use initially showed a protective role, toxicity is a concern for human health as several UV filters are endocrine-disrupting chemicals (EDCs). Exposure to EDCs may induce cardiovascular diseases and can affect the health of sensitive people, such as pregnant women. Currently, the world's most widely used UV-B filter is octylmethoxycinnamate (OMC), an EDC. However, the disruptive effects on pregnant women are little known. The present work proposed to understand how long-term exposure to OMC affects vascular homeostasis. Endothelium-denuded human umbilical artery (HUA) rings were incubated in an organ bath system. Long-term effects of exposure to OMC (0.001-50 mu mol/L) were evaluated on the contractile responses of HUA to the application of the contractile agents, serotonin (5-HT) and histamine (Hist). To investigate in more detail the vascular mode of action of OMC, through which it impairs the vascular homeostasis of HUA, the activity and expression of different 5-HT and Hist-receptors involved in contractility processes were studied. Our findings pointed out an increase in the reactivity of HUA to 5-HT and Hist due to OMC exposure. These alterations in reactivity may be precursors of preeclampsia development and/or gestational hypertension.
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