4.7 Article

Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis

Maxim L. Bychkov et al.

Summary: Extracellular acidification promotes proliferation, migration, and invasion of metastatic melanoma cells, but has no effect on normal keratinocytes. The use of ASIC1a inhibitor mambalgin-2 can suppress these processes and induce apoptosis in melanoma cells. Targeting ASIC1a with drugs like mambalgin-2 could be a promising strategy for metastatic melanoma treatment.

BIOMEDICINES (2021)

Review Cell Biology

Hypoxia and Extracellular Acidification as Drivers of Melanoma Progression and Drug Resistance

Ewelina Dratkiewicz et al.

Summary: The review discusses the role of hypoxia and acidification in melanoma progression and drug resistance, highlighting them as potential therapeutic targets. The tumor microenvironment, including stromal and immune cells, extracellular matrix, and physicochemical conditions, may also influence treatment effectiveness. Hypoxia and acidification can reprogram the metabolism of melanoma cells, promoting their survival, invasiveness, and immunosuppressive environment.
Review Oncology

Melanoma Plasticity: Promoter of Metastasis and Resistance to Therapy

Fan Huang et al.

Summary: Melanoma, the deadliest form of skin cancer, poses a significant clinical challenge despite the advancements in targeted therapies and immunotherapies. The presence of distinct cell populations with different gene signatures in melanoma leads to tumor heterogeneity and therapeutic resistance. Phenotype switching in melanoma, where cells transition to a more aggressive and therapy-resistant state, further complicates treatment strategies.

FRONTIERS IN ONCOLOGY (2021)

Letter Biotechnology & Applied Microbiology

Visualizing and interpreting cancer genomics data via the Xena platform

Mary J. Goldman et al.

NATURE BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

The multifaceted roles of tumor-associated proteases and harnessing their activity for prodrug activation

Olga Vasiljeva et al.

BIOLOGICAL CHEMISTRY (2019)

Review Oncology

AKT and ERK dual inhibitors: The way forward?

Zhe Cao et al.

CANCER LETTERS (2019)

Article Biochemistry & Molecular Biology

Signaling from mTOR to eIF2α mediates cell migration in response to the chemotherapeutic doxorubicin

Robert F. Harvey et al.

SCIENCE SIGNALING (2019)

Review Biotechnology & Applied Microbiology

miR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer

Hua Bai et al.

ONCOTARGETS AND THERAPY (2019)

Review Medicine, Research & Experimental

Diversity and functional evolution of the plasminogen activator system

Rishi Kumar Jaiswal et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Medicine, Research & Experimental

Functions and mechanisms of microRNA-31 in human cancers

Tao Yu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Oncology

HERV-K activation is strictly required to sustain CD133+melanoma cells with stemness features

Ayele Argaw-Denboba et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Article Biotechnology & Applied Microbiology

miR-31 Functions as an Oncomir Which Promotes Epithelial-Mesenchymal Transition via Regulating BAP1 in Cervical Cancer

Nan Wang et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Review Oncology

The Multiple Roles of Exosomes in Metastasis

Ulrich H. Weidle et al.

CANCER GENOMICS & PROTEOMICS (2017)

Article Medicine, Research & Experimental

Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma

Federica Felicetti et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

Article Medicine, Research & Experimental

Melanoma exosomes enable tumor tolerance in lymph nodes

Joshua L. Hood

MEDICAL HYPOTHESES (2016)

Review Oncology

Acidic tumor microenvironment in human melanoma

Ines Boehme et al.

PIGMENT CELL & MELANOMA RESEARCH (2016)

Review Cell & Tissue Engineering

The role of pluripotency factors to drive stemness in gastrointestinal cancer

Martin Mueller et al.

STEM CELL RESEARCH (2016)

Review Pharmacology & Pharmacy

Extracellular vesicles as new players in angiogenesis

Sharad Kholia et al.

VASCULAR PHARMACOLOGY (2016)

Review Medicine, General & Internal

Decoding the Secret of Cancer by Means of Extracellular Vesicles

Nobuyoshi Kosaka

JOURNAL OF CLINICAL MEDICINE (2016)

Article Multidisciplinary Sciences

miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer

Yeting Hong et al.

SCIENTIFIC REPORTS (2016)

Review Immunology

The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance

Justin M. David et al.

VACCINES (2016)

Review Cell Biology

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

Valentina R. Minciacchi et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

Article Cell Biology

AKT1 Activation Promotes Development of Melanoma Metastases

Joseph H. Cho et al.

CELL REPORTS (2015)

Review Biochemistry & Molecular Biology

New insights into IL-12-mediated tumor suppression

S. Tugues et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Biochemistry & Molecular Biology

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

Mirjam C. Boelens et al.

Article Biochemical Research Methods

Isolation of biologically-active exosomes from human plasma

Laurent Muller et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2014)

Review Biotechnology & Applied Microbiology

Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells

Catarina Roma-Rodrigues et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Oncology

Functions and therapeutic roles of exosomes in cancer

Jacob A. Tickner et al.

FRONTIERS IN ONCOLOGY (2014)

Article Cell Biology

Comparative marker analysis of extracellular vesicles in different human cancer types

Yusuke Yoshioka et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

Article Oncology

Interleukin 6 mediates production of interleukin 10 in metastatic melanoma

Mizue Terai et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

Review Medicine, Research & Experimental

miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy

M. Garofalo et al.

CURRENT MOLECULAR MEDICINE (2012)

Article Biochemistry & Molecular Biology

Anti-oncogenic MicroRNA-203 Induces Senescence by Targeting E2F3 Protein in Human Melanoma Cells

Shunsuke Noguchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Hector Peinado et al.

NATURE MEDICINE (2012)

Article Multidisciplinary Sciences

Identifying mRNA, MicroRNA and Protein Profiles of Melanoma Exosomes

Deyi Xiao et al.

PLOS ONE (2012)

Review Biochemistry & Molecular Biology

Inflammasome Activation of IL-1 Family Mediators in Response to Cutaneous Photodamage

Tahseen H. Nasti et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2012)

Article Biochemistry & Molecular Biology

MicroRNA miR-21 Regulates the Metastatic Behavior of B16 Melanoma Cells

Chuan He Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Medicine, Research & Experimental

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells

Daniel T. Fisher et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Dermatology

EGFR in melanoma: clinical significance and potential therapeutic target

Barbara Boone et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2011)

Article Multidisciplinary Sciences

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

Marc A. Antonyak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Immunology

The regulation of IL-10 production by immune cells

Margarida Saraiva et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Review Oncology

Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy

Francesco Cappello et al.

CANCER BIOLOGY & THERAPY (2008)

Meeting Abstract Oncology

MicroRNA-221/-222 pathway controls melanoma progression

F. Felicetti et al.

EJC SUPPLEMENTS (2008)

Article Cell Biology

The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase

Sachie Hiratsuka et al.

NATURE CELL BIOLOGY (2008)

Review Oncology

Cancer/testis genes expression in human melanoma cell lines

Irina N. Mikhaylova et al.

MELANOMA RESEARCH (2008)

Article Biochemistry & Molecular Biology

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

Z. Lu et al.

ONCOGENE (2008)

Article Oncology

Melanoma and the Tumor Microenvironment

Jessie Villanueva et al.

CURRENT ONCOLOGY REPORTS (2008)

Article Biochemistry & Molecular Biology

KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages

Junwen Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Ophthalmology

EGF-induced cell migration is mediated by ERK and PI3K/AKT pathways in cultured human lens epithelial cells

Q Jiang et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2006)

Article Cell Biology

Adhesion, migration and communication in melanocytes and melanoma

NK Haass et al.

PIGMENT CELL RESEARCH (2005)

Article Ophthalmology

Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium

S Saika et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2004)