期刊
BIOMEDICINES
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10061311
关键词
pediatric glioma; HGG; epigenetics; transcriptional networks; developmental programs; cell of origin; targeted therapy; clinical management
资金
- French charity Wonder Augustine
This article reviews the molecular specificities of pediatric high-grade gliomas (pHGGs) in the context of epigenomic rewiring and the co-opted transcriptional signaling pathways. Understanding the synergistic effects of transcriptional and epigenetic alterations in these tumors can help identify new therapeutic targets.
Pediatric high-grade gliomas (pHGGs) are a deadly and heterogenous subgroup of gliomas for which the development of innovative treatments is urgent. Advances in high-throughput molecular techniques have shed light on key epigenetic components of these diseases, such as K27M and G34R/V mutations on histone 3. However, modification of DNA compaction is not sufficient by itself to drive those tumors. Here, we review molecular specificities of pHGGs subcategories in the context of epigenomic rewiring caused by H3 mutations and the subsequent oncogenic interplay with transcriptional signaling pathways co-opted from developmental programs that ultimately leads to gliomagenesis. Understanding how transcriptional and epigenetic alterations synergize in each cellular context in these tumors could allow the identification of new Achilles' heels, thereby highlighting new levers to improve their therapeutic management.
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