期刊
BIOMEDICINES
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines10051079
关键词
oligonucleotides; nucleic acids; nanotubes; nanobiosensors; aptamer aptasensor(s)
资金
- RUDN University Strategic Academic Leadership Program
This review focuses on the characteristics and applications of nucleic acid aptamers, specifically DNA and RNA aptamers, and discusses the recent advances in their application in nanotechnology.
Nucleic Acid (NA) aptamers are oligonucleotides. They are unique due to their secondary and tertiary structure; namely, the secondary structure defines the tertiary one by means of affinity and specificity. Our review is devoted only to DNA and RNA aptamers, since the majority of achievements in this direction were obtained with their application. NA aptamers can be used as macromolecular devices and consist of short single-stranded molecules, which adopt unique three-dimensional structures due to the interaction of complementary parts of the chain and stacking interactions. The review is devoted to the recent nanotechnological advances in NA aptamers application.
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