4.7 Article

Vascularization of Patient-Derived Tumoroid from Non-Small-Cell Lung Cancer and Its Microenvironment

期刊

BIOMEDICINES
卷 10, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/biomedicines10051103

关键词

patient-derived tumoroid; vascularization; tumor microenvironment; lung cancer

资金

  1. Transgene SA (Illkirch Graffenstaden, France)
  2. Morocco government
  3. Erasmus fellowship (European Union)
  4. Mobint fellowship (Catalan government)

向作者/读者索取更多资源

Researchers have developed a vascularized patient-derived tumoroid model that preserves histopathological features of tumors and mimics the tumor microenvironment. This model shows promise for personalized medicine and can facilitate more accurate drug screening and treatment testing.
Patient-derived tumoroid (PDT) has been developed and used for anti-drug screening in the last decade. As compared to other existing drug screening models, a PDT-based in vitro 3D cell culture model could preserve the histological and mutational characteristics of their corresponding tumors and mimic the tumor microenvironment. However, few studies have been carried out to improve the microvascular network connecting the PDT and its surrounding microenvironment, knowing that poor tumor-selective drug transport and delivery is one of the major reasons for both the failure of anti-cancer drug screens and resistance in clinical treatment. In this study, we formed vascularized PDTs in six days using multiple cell types which maintain the histopathological features of the original cancer tissue. Furthermore, our results demonstrated a vascular network connecting PDT and its surrounding microenvironment. This fast and promising PDT model opens new perspectives for personalized medicine: this model could easily be used to test all therapeutic treatments and could be connected with a microfluidic device for more accurate drug screening.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据