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KDEL Receptors: Pathophysiological Functions, Therapeutic Options, and Biotechnological Opportunities

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Summary: The KDEL receptor undergoes a complex recycling pathway through Golgi and perinuclear recycling endosomes when expressed on the cell surface, preferring clathrin-mediated endocytic pathway and transport carriers. This suggests that the KDEL receptor may function as a bona fide cell surface receptor with a well-defined trafficking itinerary through endolysosomal compartments.

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