Structure of Some Green Tea Catechins and the Availability of Intracellular Copper Influence Their Ability to Cause Selective Oxidative DNA Damage in Malignant Cells

Review Biochemistry & Molecular Biology

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

Maleki Parisa Dana et al.

Summary: Polyphenols, natural compounds with beneficial properties, can increase the sensitivity of cancer cells to chemotherapeutic agents and affect other mechanisms for overcoming chemoresistance in cancer cells.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Biochemistry & Molecular Biology

Copper in tumors and the use of copper-based compounds in cancer treatment

Daniela Almeida da Silva et al.

Summary: Copper ions have shown potential in cancer therapy, especially when complexed with organic counterparts. Studies have also suggested using copper in nanoparticles for imaging and treating hypoxic tumors, but challenges remain in their solubility and mechanism of action.

JOURNAL OF INORGANIC BIOCHEMISTRY (2022)

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Review Oncology

Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge et al.

Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.

NATURE REVIEWS CANCER (2022)

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Review Biochemistry & Molecular Biology

Copper metabolism as a unique vulnerability in cancer

Vinit C. Shanbhag et al.

Summary: Over the past 25 years, significant progress has been made in identifying and characterizing proteins that regulate the uptake, intracellular trafficking and export of copper. While copper is essential for growth and development in humans and other mammals, it is also a limiting nutrient for cancer cell growth and proliferation. Oral copper chelators have been shown to have anti-neoplastic and anti-metastatic effects in animals and humans.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article

The Impact of EGCG and RG108 on SOCS1 Promoter DNA Methylation and Expression in U937 Leukemia Cells

Mohsen Alizadeh et al.

Reports of Biochemistry and Molecular Biology (2021)

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Review Pharmacology & Pharmacy

Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways

Manuel Humberto Chairez-Ramirez et al.

Summary: Polyphenols have been shown to regulate signaling pathways central to cancer development, progression, and metastasis. They induce protein modifications, particularly on p53, influencing its role in DNA damage response, apoptosis control, and cell-fate decisions. Understanding the effects of polyphenols on key players in cancer-driving signaling pathways can lead to improved targeted therapies with reduced toxicity for cancer treatment.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Spectroscopy