期刊
JOURNAL OF INFLAMMATION RESEARCH
卷 15, 期 -, 页码 3083-3094出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S350109
关键词
neuroimmune; autonomic nervous system; central-peripheral crosstalk; sympathetic nervous system
类别
资金
- National Natural Science Foundation of China [82100292, 82070436, 81970287]
- Natural Science Foundation of Hubei Province [2020CFB234]
Microglia play a crucial role in the central nervous system and targeting them can improve the prognosis of neurological diseases. Recent studies have also found a connection between microglia and cardiovascular diseases, with interventions regulating their activity modulating the incidence and progression of these diseases.
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown to improve the prognosis of various neurological diseases. Recently, studies have observed the activation of microglia in different cardiovascular diseases. In addition, different approaches that regulate the activity of microglia have been shown to modulate the incidence and progression of cardiovascular diseases. The change in autonomic nervous system activity after neuroinflammation may be a potential intermediate link between microglia and cardiovascular diseases. Here, in this review, we will discuss recent updates on the regulatory role of microglia in hypertension, myocardial infarction and ischemia/reperfusion injury. We propose that microglia serve as neuroimmune modulators and potential targets for cardiovascular diseases.
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