期刊
JOURNAL OF INFLAMMATION RESEARCH
卷 15, 期 -, 页码 2281-2294出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S359042
关键词
anti-oral mucosal ulcer; anti-inflammation; Kaempferia galanga L; wound healing
类别
资金
- UNIVERSITAS PADJADJARAN via the Directorate of Research and Community Engagement [1595/UN6.3.1/PT.00/2021]
This study found that Kaempferia galanga L. extract can effectively reduce inflammation and promote healing of chemical-induced oral mucosal ulcers. Topical application of the extract was more effective than the conventional therapy triamcinolone acetonide.
Introduction: Kaempferia galanga L. (K. galanga; local name kencur, Zingiberaceae) is a plant commonly used as a kitchen spice, and empirically it is often used for medicinal purposes. This plant has been shown to have an anti-inflammatory role, but no research has been found on its effect on oral mucosal ulcer. This study aimed to investigate anti-inflammatory activity and wound healing effect of the ethanol extract of K. galanga L. rhizome (EEKG) on the chemical-induced oral mucosal ulcer in Wistar rats. Methods: In this study, 35 rats were divided into 7 groups (normal, negative, triamcinolone acetonide, and 4 EEKG groups). Acetic acid 70% was used as the oral mucosal ulcer inducer. Parameters observed were macroscopic and microscopic histopathological examinations. Results: The results revealed that dose of 0.5% of the EEKG was effective in increasing the percent recovery of ulcer area and inflammation sign scores. Meanwhile, doses of 0.5-2% of EEKG were effective in reducing the histopathological score. Interestingly, topical EEKG in our study was more effective compared with triamcinolone acetonide (the conventional therapy for oral mucosal ulceration). Discussion: The EEKG has been confirmed its anti-inflammatory activity by accelerating the healing process on the chemical-induced oral mucosal ulcer in Wistar rats, based on the percent recovery of the ulcer area, the percent recovery of the inflammation sign score, and the histopathology score. Conclusion: Taken together, K. galanga L. is very potential to be developed as a prospective phytopharmaceutical for the treatment of oral mucosal ulceration in human after clinical trials.
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