期刊
JOURNAL OF INFLAMMATION RESEARCH
卷 15, 期 -, 页码 2181-2198出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S353467
关键词
brain injuries; cell death; COVID-19; ferroptosis; iron; neuropsychiatric symptoms
类别
资金
- Education and Teaching Reform Research and Practice project of Zhengzhou University [2021ZZUJGLX219]
This review discusses the potential pathogenic role of ferroptosis in COVID-19-related brain injury and the possible routes by which SARS-CoV-2 could invade the brain. Understanding these mechanisms could lead to new treatment strategies to prevent or reduce brain-related complications of COVID-19.
The COVID-19 pandemic has caused devastating loss of life and a healthcare crisis worldwide. SARS-CoV-2 is the causative pathogen of COVID-19 and is transmitted mainly through the respiratory tract, where the virus infects host cells by binding to the ACE2 receptor. SARS-CoV-2 infection is associated with acute pneumonia, but neuropsychiatric symptoms and different brain injuries are also present. The possible routes by which SARS-CoV-2 invades the brain are unclear, as are the mechanisms underlying brain injuries with the resultant neuropsychiatric symptoms in patients with COVID-19. Ferroptosis is a unique iron-dependent form of non-apoptotic cell death, characterized by lipid peroxidation with high levels of glutathione consumption. Ferroptosis plays a primary role in various acute and chronic brain diseases, but to date, ferroptosis in COVID-19-related brain injuries has not been explored. This review discusses the mechanisms of ferroptosis and recent evidence suggesting a potential pathogenic role for ferroptosis in COVID-19-related brain injury. Furthermore, the possible routes through which SARS-CoV-2 could invade the brain are also discussed. Discoveries in these areas will open possibilities for treatment strategies to prevent or reduce brain-related complications of COVID-19.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据