4.7 Article

Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

ROS1-dependent cancers - biology, diagnostics and therapeutics

Alexander Drilon et al.

Summary: The proto-oncogene ROS1 encodes a receptor tyrosine kinase without a well-defined physiological role, and somatic chromosomal fusions involving ROS1 lead to chimeric oncoproteins that drive various cancers. Although ROS1-directed tyrosine kinase inhibitors show therapeutic efficacy, resistance mechanisms remain unclear.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Oncology

Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer

Jessica J. Lin et al.

Summary: The study revealed that mutations in the ROS1 gene play a significant role in resistance to both crizotinib and lorlatinib in ROS1(+) NSCLC patients, with the most common mutations being ROS1 G2032R and L2086F. Additionally, other resistance mechanisms were identified in lorlatinib-resistant patients, including MET amplification and KRAS mutations. Continued efforts are required to elucidate ROS1-independent resistance mechanisms.

CLINICAL CANCER RESEARCH (2021)

Article Medicine, General & Internal

Clinical and molecular factors that impact the efficacy of first-line crizotinib in ROS1-rearranged non-small-cell lung cancer: a large multicenter retrospective study

Yongchang Zhang et al.

Summary: Our study demonstrates that baseline brain metastatic status and various molecular factors may contribute to distinct clinical outcomes from first-line crizotinib therapy in patients with ROS1-rearranged lung cancer.

BMC MEDICINE (2021)

Article Oncology

Molecular Analysis of Plasma From Patients With ROS1-Positive NSCLC

Ibiayi Dagogo-Jack et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

Article Oncology

Resistance Mechanisms to Targeted Therapies in ROS1(+) and ALK(+) Non-small Cell Lung Cancer

Caroline E. McCoach et al.

CLINICAL CANCER RESEARCH (2018)

Review Oncology

Recent Advances in Targeting ROS1 in Lung Cancer

Jessica J. Lin et al.

JOURNAL OF THORACIC ONCOLOGY (2017)

Article Multidisciplinary Sciences

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

Helen Y. Zou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Oncology

Activation of RAS family members confers resistance to ROS1 targeting drugs

Marilisa Cargnelutti et al.

ONCOTARGET (2015)

Letter Medicine, General & Internal

Case 16-2013: A Girl with Irritability, Hypersomnia, and Somatic Symptoms

Linda Shavit et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)