期刊
NPJ PRECISION ONCOLOGY
卷 6, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41698-022-00264-w
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资金
- Natural Science Foundation of Hunan Province [2020SK2031, kq1801102, 2020SK2030, 2018RS3106, 2019-TJ-N04, 2019SK4010, 2020JJ3025]
- CAS Light of West China Program
This retrospective study investigated the association between disease progression pattern and acquired resistance mechanism in patients with ROS1-rearranged non-small-cell lung cancer treated with crizotinib. The study found that treatment-emergent ROS1 point mutations were the major molecular mechanism of crizotinib resistance, particularly in patients with extracranial-only disease progression. The findings emphasize the importance of rebiopsy and gene testing for subsequent-line therapeutic management.
This retrospective study investigated the association between the pattern of disease progression and molecular mechanism of acquired resistance in a large cohort of 49 patients with ROS1-rearranged advanced non-small-cell lung cancer treated with first-line crizotinib. We found that treatment-emergent ROS1 point mutations were the major molecular mechanism of crizotinib resistance, particularly for patients who developed extracranial-only disease progression. Our findings highlight the importance of rebiopsy and gene testing for subsequent-line therapeutic management.
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