期刊
CLINICAL AND TRANSLATIONAL MEDICINE
卷 12, 期 5, 页码 -出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ctm2.864
关键词
assisted reproductive technology; deleterious mutations; genetic load; human fertility
资金
- Earth and Life Systems Alliance (ELSA), Norwich Research Park
- Biotechnology and Biological Sciences Research Council (BBSRC) - Doctoral Training Partnership
- European Research Council (ERC)
This article discusses the significant impact of genetic load on assisted reproductive technology, human reproduction, and fertility. It explores these topics in the context of evolutionary genetic theory, the technological revolution in ART, and the advancements in genomics and bioinformatics.
The genetic load in the human genome has important ramifications for assisted reproductive technology (ART), human reproduction and fertility more generally. Here, we discuss these topics in the light of evolutionary genetic theory, the technological revolution in ART and the advances in the fields of genomics and bioinformatics.
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