Targeting inflammation with collagen

Tissue damage caused by an infection oran autoimmune disease triggers degradation of collagen in the extracellular matrix (ECM), which further enhances inflammation. Therefore, improving ECM in aninflamed tissue can be exploited as a potential therapeutic target. A recentstudy emphasised an innovative approach against COVID-19 using polymerised type I collagen (PTIC) that improves disease severity through a hitherto unknownmechanism. In this paper, we provide an overview of potential mechanism thatmay explain the anti-inflammatory effect of collagen peptides. In addition,the paper includes a brief summary of possible side effect of collagendeposition in inflammatory diseases. Altogether, current knowledge suggeststhat collagen may potentially reduce the residual risk in inflammatorydiseases; however, the detailed mechanism remains elusive.

Automated summary

This paper provides an overview of the potential mechanisms explaining the anti-inflammatory effects of collagen peptides. It also discusses the possible risks of collagen deposition in inflammatory diseases. Although the detailed mechanisms remain unclear, current knowledge suggests that collagen may be a potential therapeutic option for reducing the residual risk in inflammatory diseases.