Targeting the cutaneous microbiota in atopic dermatitis: 'A new hope' or 'attack of the CoNS'? COMMENT

Although evidence showing that Staphylococcus aureus (S. aureus) is directly causative of atopic dermatitis (AD) is still lacking, there is evidence that S. aureus abundance is associated with disease flares and therapeutic responses. Patients receiving ATx201 OINTMENT 2% twice-daily had a significant reduction in the abundance of S. aureus and increasing Shannon diversity of skin microbiome compared to vehicle after seven days. A small molecule with a narrow-spectrum effect, especially on S. aureus, might be an attractive alternative for the treatment of AD.

Automated summary

Although direct causation between S. aureus and AD is still lacking, there is evidence of its association with disease flares and therapeutic responses. Treatment with ATx201 OINTMENT 2% twice-daily resulted in a significant reduction in S. aureus abundance and increased diversity of the skin microbiome, making it a potential alternative for AD treatment.