期刊
CLINICAL AND TRANSLATIONAL MEDICINE
卷 12, 期 4, 页码 -出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ctm2.833
关键词
cyclin C; chemotherapy; gastric cancer
资金
- Major Project for Science and Technology Innovation 2025 of Ningbo [2019B10037]
- K.C. Wong Magna Fund in Ningbo University
The resistance to cisplatin-based chemotherapy is a common cause of poor prognosis in cancer patients. Recent research has found that ubiquitylation and translocation of cyclin C in cancer cells can affect the stability of mitochondria after cisplatin stimulation, providing new insights for studying chemoresistance mechanisms and developing new chemotherapy drugs.
The resistance to cisplatin-based chemotherapy is a common cause of poor prognosis in cancer patients. Cisplatin stimulation causes cyclin C translocating to mitochondria, and in turn induces mitochondrial fission. However, little is known about the role of cyclin C in mitochondrial dysfunction in cancer cells challenged with cisplatin. In the present commentary, we bring to the attention of readers the recent report by Jiang et al which revealed the importance of ubiquitylation and translocation of cyclin C in gastric cancer cells in response to cisplatin stimulation for mitochondrial stability. This finding provides new insights into exploring the novel mechanisms of chemoresistance and developing the new chemotherapy synergistic agents in the era of precision oncology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据