Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering

Article Dentistry, Oral Surgery & Medicine

The intrasulcular application effect of bisphosphonate hydrogel toward osteoclast activity and relapse movement

Tita Ratya Utari et al.

Summary: The controlled release of bisphosphonate risedronate with gelatin hydrogel as a carrier has shown efficacy in decreasing tooth relapse movement and osteoclast activity.

SAUDI DENTAL JOURNAL (2021)

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Article Materials Science, Biomaterials

Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications

K. Zafeiris et al.

Summary: Additive manufacturing was used to create 3D scaffolds for bone tissue engineering by synthesizing hybrid hydroxyapatite hydrogels through a bioinspired approach, with modifications in rheology and printing parameters to optimize the final product. Evaluation of porosity and biocompatibility demonstrated that the scaffolds had suitable properties for cell adhesion and viability.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Engineering, Biomedical

Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization

Chong Wang et al.

Summary: 3D printing is increasingly used to create advanced bone tissue engineering scaffolds with biomimetic structures and matched mechanical strengths for improved bone regeneration. Customized scaffolds were produced using cryogenic 3D printing of beta-tricalcium phosphate and osteogenic peptide inks, and coated with angiogenic peptide hydrogel to enhance vascularization. The scaffolds had a hierarchically porous structure similar to human cancellous bone and showed high viability for both endothelial cells and mesenchymal stem cells. Improved in vitro migration and angiogenesis were observed for scaffolds with angiogenic peptide, while enhanced osteogenic differentiation was seen in scaffolds containing osteogenic peptide. In vivo, scaffolds with both peptides showed increased angiogenesis and new bone formation.

BIOACTIVE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

One-Pot Hydrothermal Synthesis of Solution-Processable MoS2/PEDOT:PSS Composites for High-Performance Supercapacitors

Yunfeng Chao et al.

Summary: The study introduces a polymer into the precursor to inhibit the self-assembly of MoS2 nanosheets, forming a MoS2/PEDOT:PSS hydrogel in the hydrothermal process, which can be used to prepare free-standing flexible films or for 3D printing. The resulting MP film displays excellent electrochemical performance and high capacitance retention rates after bending cycles in various electrolytes.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Cadmium Selenide Quantum Dots for Solar Cell Applications: A Review

Mohammad Mominur Rahman et al.

Summary: Quantum dot-sensitized solar cells are important energy-producing devices with potential for higher efficiency, but face challenges due to narrow absorption areas and charge recombination, requiring new electrodes, sensitizers, and electrolytes for improvement.

CHEMISTRY-AN ASIAN JOURNAL (2021)

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Review Engineering, Biomedical

Advancing application of mesenchymal stem cell-based bone tissue regeneration

Fengqing Shang et al.

Summary: The utilization of regenerative biomaterials for bone repair requires not only efficacy and safety, but also cost-effectiveness and convenience. Understanding the roles of regenerative biomaterials and mesenchymal stem cells in new bone formation can potentially open new opportunities in the field of bone regeneration.

BIOACTIVE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Alina Kirillova et al.

Summary: The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.

CHEMICAL REVIEWS (2021)

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Article Engineering, Biomedical

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies

Zechuan Zhang et al.

Summary: The novel biodegradable metal system of ZnLiCa ternary alloys showed comparable tensile strength to pure Ti and great potential for bone defect regeneration. The alloys demonstrated good biocompatibility and osteogenesis-promoting effects.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Zn0.8Li0.1Sr-a biodegradable metal with high mechanical strength comparable to pure Ti for the treatment of osteoporotic bone fractures: In vitro and in vivo studies

Zechuan Zhang et al.

Summary: The study presents the first in vivo investigation of a Zn-based biodegradable metal for treating osteoporotic bone fractures, demonstrating excellent mechanical properties and superior osteogenesis-inducing and osteoporotic-bone-fracture-treating effects compared to pure Ti.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Degradable photothermal bioactive glass composite hydrogel for the sequential treatment of tumor-related bone defects: From anti-tumor to repairing bone defects

Zhen Yang et al.

Summary: The study developed double crosslinking injectable composite hydrogels for the treatment of tumor-related irregular bone defects, which combine both tumor therapy and bone regeneration functions. The composite hydrogel exhibited excellent photothermal effects, inhibiting tumor growth in mice and promoting new bone formation.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics

Kunyu Zhang et al.

Summary: Hydrogels are gaining increasing attention in biomedical studies due to their unique chemical and physical properties. Dynamic hydrogels, which can better mimic the functions of natural extracellular matrix, have shown promise in applications such as regenerative medicine and drug delivery. Recent research has focused on the fabrication strategies and unique properties of dynamic hydrogels, as well as discussing challenges and emerging trends in their development and application.

CHEMICAL REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Preparation of microfluidic-based pectin microparticles loaded carbon dots conjugated with BMP-2 embedded in gelatin-elastin-hyaluronic acid hydrogel scaffold for bone tissue engineering application

Alireza Rajabnejadkeleshteri et al.

Summary: The study developed a controlled BMP-2-CDs release system by encapsulating BMP-2-CDs in pectin microparticles using a microfluidic approach, and incorporating them into composite scaffolds made of gelatin, elastin, and hyaluronic acid. The system demonstrated a high controlled delivery capacity for bone regeneration and has promising potential in the field.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Self-healable and flexible supramolecular gelatin/MoS2 hydrogels with molecular recognition properties

Zeinab Zohreband et al.

Summary: The specific interactions between MoS2 and gelatin matrix resulted in a biomimetic hydrogel with self-healing and molecular recognition properties, showing promise for future biomedical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Multidisciplinary Sciences

Gradient bimetallic ion-based hydrogels for tissue microstructure reconstruction of tendon-to-bone insertion

Renhao Yang et al.

Summary: The gradient bimetallic ion-based hydrogel, constructed through one-step coordinative crosslinking of sulfhydryl groups with copper and zinc ions, can induce regenerative capacity in vitro while simultaneously promoting tenogenesis and osteogenesis, showing significant effects on tissue regeneration in a rat rotator cuff tear model.

SCIENCE ADVANCES (2021)

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Article Engineering, Environmental

3D printing electrospinning fiber-reinforced decellularized extracellular matrix for cartilage regeneration

Weiming Chen et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Instruments & Instrumentation

A collagen-based hydrogel containing tacrolimus for bone tissue engineering

Mir Hamed Nabavi et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Bioinspired Mineral-Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

Shumeng Bai et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Engineering, Biomedical

Progress in 3D bioprinting technology for tissue/organ regenerative engineering

Ishita Matai et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Porous PVA/SA/HA hydrogels fabricated by dual-crosslinking method for bone tissue engineering

Mengjie Xu et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2020)

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Review Biochemistry & Molecular Biology

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

Mariana I. Neves et al.

MOLECULES (2020)

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Article Chemistry, Multidisciplinary

Nanoparticle-hydrogel superstructures for biomedical applications

Yao Jiang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Correction Chemistry, Multidisciplinary

Intensified Stiffness and Photodynamic Provocation in a Collagen-Based Composite Hydrogel Drive Chondrogenesis (vol 6, 1900099, 2019)

Li Zheng et al.

ADVANCED SCIENCE (2020)

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Article Nanoscience & Nanotechnology

Integration of Macro-Cross-Linker and Metal Coordination: A Super Stretchable Hydrogel with High Toughness

Rita Das Mahapatra et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Multifunctional Supramolecular Hydrogel for Prevention of Epidural Adhesion after Laminectomy

Yan Wang et al.

ACS NANO (2020)

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Review Chemistry, Multidisciplinary

Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application

Hongyuan Zhu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Guiding Lights: Tissue Bioprinting Using Photoactivated Materials

Mihyun Lee et al.

CHEMICAL REVIEWS (2020)

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Review Plant Sciences

Gardenia jasminoides Ellis: Ethnopharmacology, phytochemistry, and pharmacological and industrial applications of an important traditional Chinese medicine

Liping Chen et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Engineering, Biomedical

Biological and mechanical performance and degradation characteristics of calcium phosphate cements in large animals and humans

Lena Schroeter et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Multidisciplinary

Inspired by Nature: Facile Design of Nanoclay-Organic Hydrogel Bone Sealant with Multifunctional Properties for Robust Bone Regeneration

Chung-Sung Lee et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Cell Biology

Mechanisms of bone development and repair

Ankit Salhotra et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Pharmacology & Pharmacy

Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Soluplus® Polymeric Micelles Encapsulating Fenbendazole

Ik Sup Jin et al.

PHARMACEUTICS (2020)

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Review Biochemistry & Molecular Biology

Stress, inflammation, depression, and dementia associated with phosphate toxicity

Ronald B. Brown

MOLECULAR BIOLOGY REPORTS (2020)

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Review Cell & Tissue Engineering

Regeneration of skeletal system with genipin crosslinked biomaterials

Zhonghan Wang et al.

JOURNAL OF TISSUE ENGINEERING (2020)

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Article Chemistry, Analytical

Developing a colorimetric nucleic acid-responsive DNA hydrogel using DNA proximity circuit and catalytic hairpin assembly

Sima Khajouei et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Polymer Science

Poly(N,N′-Diethylacrylamide)-Based Thermoresponsive Hydrogels with Double Network Structure

Lenka Hanykova et al.

POLYMERS (2020)

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Review Pharmacology & Pharmacy

Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology

Athira R. Nair et al.

AAPS PHARMSCITECH (2020)

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Article Materials Science, Biomaterials

Rapid and cytocompatible cell-laden silk hydrogel formation via riboflavin-mediated crosslinking

Susanna Piluso et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Materials Science, Biomaterials

Temperature-responsive supramolecular hydrogels

Sijie Xian et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Materials Science, Biomaterials

An injectable BMSC-laden enzyme-catalyzed crosslinking collagen-hyaluronic acid hydrogel for cartilage repair and regeneration

Yajie Zhang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Materials Science, Biomaterials

Engineered macroporous hydrogel scaffolds via pickering emulsions stabilized by MgO nanoparticles promote bone regeneration

Haotian Pan et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Engineering, Biomedical

3D printing of bone tissue engineering scaffolds

Chong Wang et al.

BIOACTIVE MATERIALS (2020)

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Article Engineering, Biomedical

Combinatorial effects of inorganic ions on adhesion and proliferation of osteoblast-like cells

Akiko Obata et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

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Article Materials Science, Biomaterials

Injectable hydrogels from enzyme-catalyzed crosslinking as BMSCs-laden scaffold for bone repair and regeneration

Yajie Zhang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Polymer Science

A Composite Hydrogel with High Mechanical Strength, Fluorescence, and Degradable Behavior for Bone Tissue Engineering

Yanqin Wang et al.

POLYMERS (2019)

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Review Engineering, Biomedical

Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Kamil Elkhoury et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Nanoscience & Nanotechnology

PCL-MECM-Based Hydrogel Hybrid Scaffolds and Meniscal Fibrochondrocytes Promote Whole Meniscus Regeneration in a Rabbit Meniscectomy Model

Mingxue Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Engineering, Biomedical

An injectable collagen-genipin-carbon dot hydrogel combined with photodynamic therapy to enhance chondrogenesis

Zhenhui Lu et al.

BIOMATERIALS (2019)

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Article Multidisciplinary Sciences

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Zhong-Kai Cui et al.

NATURE COMMUNICATIONS (2019)

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Article Nanoscience & Nanotechnology

Black Phosphorus Hydrogel Scaffolds Enhance Bone Regeneration via a Sustained Supply of Calcium-Free Phosphorus

Keqing Huang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Materials Science, Biomaterials

Advances in crosslinking strategies of biomedical hydrogels

Weikang Hu et al.

BIOMATERIALS SCIENCE (2019)

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Review Nanoscience & Nanotechnology

Polydopamine Surface Chemistry: A Decade of Discovery

Ji Hyun Ryu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Engineering, Biomedical

Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration

Zhengjie Lin et al.

BIOMATERIALS (2018)

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Article Engineering, Environmental

Hybrid injectable platforms for the in situ delivery of therapeutic ions from mesoporous glasses

C. Pontremoli et al.

CHEMICAL ENGINEERING JOURNAL (2018)

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Review Biochemistry & Molecular Biology

Chemical crosslinking of biopolymeric scaffolds: Current knowledge and future directions of crosslinked engineered bone scaffolds

Ahmad Oryan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Endocrinology & Metabolism

The Metabolic Microenvironment Steers Bone Tissue Regeneration

Julia Loeffler et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

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Article Engineering, Biomedical

Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture

Barbara L. Ekerdt et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Materials Science, Multidisciplinary

Multifunctional Surface Modification of Mulberry Silk Fabric via PNIPAAm/Chitosan/PEO Nanofibers Coating and Cross-Linking Technology

Jia Li et al.

COATINGS (2018)

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Article Materials Science, Biomaterials

Promotion of chondrogenic differentiation of mesenchymal stem cells by copper: Implications for new cartilage repair biomaterials

Changkui Xu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Nanoscience & Nanotechnology

Multifunctional Copper-Containing Carboxymethyl Chitosan/Alginate Scaffolds for Eradicating Clinical Bacterial Infection and Promoting Bone Formation

Yao Lu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Biochemistry & Molecular Biology

The Influence of the Dietary Cu-Glycine Complex on the Histomorphology of Cancellous Bone, Articular Cartilage, and Growth Plate as well as Bone Mechanical and Geometric Parameters Is Dose Dependent

Ewa Tomaszewska et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2017)

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Article Multidisciplinary Sciences

Enzymatic mineralization generates ultrastiff and tough hydrogels with tunable mechanics

Nicolas Rauner et al.

NATURE (2017)

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Review Cell & Tissue Engineering

Injectable hydrogels for cartilage and bone tissue engineering

Mei Liu et al.

BONE RESEARCH (2017)

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Article Clinical Neurology

Efficacy of Poly(D,L-Lactic Acid-co-Glycolic acid)Poly(Ethylene Glycol)-Poly(D, L-Lactic Acid-co-Glycolic Acid) Thermogel As a Barrier to Prevent Spinal Epidural Fibrosis in a Postlaminectomy Rat Model

Xiangqian Li et al.

CLINICAL SPINE SURGERY (2017)

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Article Engineering, Biomedical

Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons

Maroof M. Adil et al.

BIOMATERIALS (2017)

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Review Chemistry, Multidisciplinary

The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering

Yulin Li et al.

CHEMICAL REVIEWS (2017)

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Article Biophysics

Novel self-assembled tacrolimus nanoparticles cross-linking thermosensitive hydrogels for local rheumatoid arthritis therapy

Huimin Wu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Chemistry, Physical

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

Ovijit Chaudhuri et al.

NATURE MATERIALS (2016)

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Article Chemistry, Multidisciplinary

Controlling Hydrogel Mechanics via Bio-Inspired Polymer-Nanoparticle Bond Dynamics

Qaochu Li et al.

ACS NANO (2016)

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Article Engineering, Biomedical

Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation

Fraz Anjum et al.

BIOMATERIALS (2016)

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Article Engineering, Biomedical

Fabrication of anatomically-shaped cartilage constructs using decellularized cartilage-derived matrix scaffolds

Christopher R. Rowland et al.

BIOMATERIALS (2016)

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Review Chemistry, Multidisciplinary

Supramolecular polymer networks: hydrogels and bulk materials

Lenny Voorhaar et al.

CHEMICAL SOCIETY REVIEWS (2016)

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Review Pharmacology & Pharmacy

Methods of synthesis of hydrogels ... A review

Muhammad Faheem Akhtar et al.

SAUDI PHARMACEUTICAL JOURNAL (2016)

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Review Biotechnology & Applied Microbiology

Engineering responsive supramolecular biomaterials: Toward smart therapeutics

Matthew J. Webber

BIOENGINEERING & TRANSLATIONAL MEDICINE (2016)

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Article Engineering, Biomedical

Nanostructured hydroxyapatite surfaces-mediated adsorption alters recognition of BMP receptor IA and bioactivity of bone morphogenetic protein-2

Baolin Huang et al.

ACTA BIOMATERIALIA (2015)

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Article Polymer Science

Synthesis and characterization of temperature-sensitive hydrogels

Xiangming Hu et al.

E-POLYMERS (2015)

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Article Engineering, Biomedical

Injectable thermosensitive PEG-PCL-PEG hydrogel/acellular bone matrix composite for bone regeneration in cranial defects

PeiYan Ni et al.

BIOMATERIALS (2014)

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Article Engineering, Biomedical

RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration

Jing Zhang et al.

BIOMATERIALS (2013)

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Article Chemistry, Applied

Development and characterization of novel alginate-based hydrogels as vehicles for bone substitutes

D. S. Morais et al.

CARBOHYDRATE POLYMERS (2013)

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Review Cell & Tissue Engineering

Bone Regeneration Based on Tissue Engineering Conceptions - A 21st Century Perspective

Jan Henkel et al.

BONE RESEARCH (2013)

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Article Engineering, Biomedical

Injectable and thermo-sensitive PEG-PCL-PEG copolymer/collagen/n-HA hydrogel composite for guided bone regeneration

ShaoZhi Fu et al.

BIOMATERIALS (2012)

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Article Engineering, Biomedical

Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography

Robert Gauvin et al.

BIOMATERIALS (2012)

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Review Chemistry, Multidisciplinary

Biopolymer-Based Hydrogels for Cartilage Tissue Engineering

Biji Balakrishnan et al.

CHEMICAL REVIEWS (2011)

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Review Cell Biology

The role of bone in phosphate metabolism

Seiji Fukumoto

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

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Article Cell & Tissue Engineering

Chondrogenic Differentiation of Adipose-Derived Adult Stem Cells by a Porous Scaffold Derived from Native Articular Cartilage Extracellular Matrix

Nai-Chen Cheng et al.

TISSUE ENGINEERING PART A (2009)

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Article Cell Biology

Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies

A. Stolzing et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2008)

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Article Chemistry, Physical

The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder

Matthew J. Dalby et al.

NATURE MATERIALS (2007)

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Article Biophysics

Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs

BJ Dubin-Thaler et al.

BIOPHYSICAL JOURNAL (2004)

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Review Pharmacology & Pharmacy

Novel crosslinking methods to design hydrogels

WE Hennink et al.

ADVANCED DRUG DELIVERY REVIEWS (2002)

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Article Biochemistry & Molecular Biology

Mitogenic G(i) protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: Activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)] and attenuation of activation by cAMP

N Gabarin et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2001)

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Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering

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