期刊
BIOACTIVE MATERIALS
卷 12, 期 -, 页码 97-106出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.10.028
关键词
Chlorella; Photodynamic therapy; Controlled adjuvants release; Systemic antitumor immune response; Immune memory effect
资金
- National Key R&D Program of China [2017YFA0205400]
- National Natural Science Foundation of China [31872755, 81872811, 32171372]
- Jiangsu Outstanding Youth Funding [BK20190007]
- Central Fundamental Research Funds for the Central Universities [02141438473]
Research has shown that using Chlorella in combination with photodynamic therapy (PDT) can enhance local tumor killing, improve the hypoxic and immunosuppressive microenvironment, increase the anti-tumor effect and immune response, and generate a stronger anti-tumor immune memory effect.
The ideal photodynamic therapy (PDT) should effectively remove the primary tumor, and produce a stronger immune memory effect to inhibit the tumor recurrence and tumor metastasis. However, limited by the hypoxic and immunosuppressive microenvironment, the PDT efficiency is apparently low. Here, Chlorella (Chl.) is exploited to enhance local effect by producing oxygen to reverse hypoxia, and release adjuvants to reverse immunosuppressive microenvironment to enhance abscopal effect afterwards. Results from different animal models indicated that Chl. could enhance local effect and PDT related immune response. Ultimately, Chl. coupled PDT elicited anti-tumor effects toward established primary tumors (inhibition rate: 90%) and abscopal tumors (75%), controlled the challenged tumors (100%) and alleviated metastatic tumors (90%). This Chl. coupled PDT strategy can also produce a stronger anti-tumor immune memory effect. Overall, this Chl. coupled PDT strategy generates enhanced local tumor killing, boosts PDT-induced immune responses and promotes anti-tumor immune memory effect, which may be a great progress for realizing systemic effect of PDT.
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