期刊
SMALL METHODS
卷 6, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smtd.202200226
关键词
circulating cancer-related cells; circulating tumor cells; clinical application; CTCs detection; microfluidic technologies
资金
- National Key Research and Development Program of China [2017YFA0205303]
Circulating tumor cells (CTCs) enumeration is widely used for early diagnoses, chemotherapy efficacy evaluation, and cancer prognosis. New types of circulating cancer-related cells have been reported to be correlated to cancer diagnosis, metastasis, or prognosis, and they present challenges to microfluidic devices for CTCs detection. This review focuses on the properties and clinical significance of these novel circulating cancer-related cells, and discusses the challenges they pose to microfluidic chip enrichment.
Circulating tumor cells (CTCs) enumeration has been widely used as a surrogate predictive marker for early diagnoses, the evaluation of chemotherapy efficacy, and cancer prognosis. Microfluidic technologies for CTCs enrichment and detection have been developed and commercialized as automation platforms. Currently, in addition to CTCs, some new types of circulating cancer-related cells (e.g., CCSCs, CTECs, CAMLs, and heterotypic CTC clusters) in circulation are also reported to be correlated to cancer diagnosis, metastasis, or prognosis. And they widely differ from the conventional CTCs in positive markers, cellular morphology, or size, which presents a new technological challenge to microfluidic devices that use affinity-based capture methods or size-based filtration methods for CTCs detection. This review focuses on the biological and physical properties as well as clinical significance of the novel circulating cancer-related cells, and discusses the challenges of their discovery to microfluidic chip for enrichment. Finally, the current challenges of CTCs detection in clinical application and future opportunities are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据