期刊
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
卷 68, 期 1, 页码 89-96出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0000000000000380
关键词
chrysin; quercetin; luteolin; inflammation; atherosclerosis; flavonoid; bioavailability
资金
- Department of Biotechnology (DBT), Government of India [BT/469/NE/TBP/2013, BT/410/NE/U-Excel/2013]
- DBT
- Department of Science and Technology (DST), Government of India
Cardiovascular diseases (CVDs) are the commonest cause of global mortality and morbidity. Atherosclerosis, the fundamental pathological manifestation of CVDs, is a complex process and is poorly managed both in terms of preventive and therapeutic intervention. Aberrant lipid metabolism and chronic inflammation play critical roles in the development of atherosclerosis. These processes can be targeted for effective management of the disease. Although managing lipid metabolism is in the forefront of current therapeutic approaches, controlling inflammation may also prove to be crucial for an efficient treatment regimen of the disease. Flavonoids, the plant-derived polyphenols, are known for their antiinflammatory properties. This review discusses the possible antiatherogenic role of 3 flavonoids, namely, chrysin, quercetin, and luteolin primarily known for their antiinflammatory properties.
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