期刊
NATURE CATALYSIS
卷 5, 期 5, 页码 388-396出版社
NATURE PORTFOLIO
DOI: 10.1038/s41929-022-00775-6
关键词
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资金
- National Key Research and Development Program of China [2020YFA0907800, 2021YFA0911000, 2021YFA1500500, 2019YFA0405600]
- National Science Fund for Distinguished Young Scholars [21925204]
- National Natural Science Foundation of China (NSFC) [U19A2015]
- Dalian National Laboratory (DNL) Cooperation Fund, Chinese Academy of Science (CAS) [DNL202003]
- K. C.Wong Education [GJTD-2020-15]
- Fundamental Research Funds for the Central Universities
- Provincial Key Research and Development Program of Anhui [202004a05020074]
- University of Science and Technology of China (USTC) Research Funds of the Double First-Class Initiative [YD2340002002]
- NSFC [22102018, 52171201, 32071416, 22005291]
- Central Government Funds of Guiding Local Scientific and Technological Development for Sichuan Province [2021ZYD0043]
- University of Electronic Science and Technology of China [A1098531023601264, A1098531023601356]
- Shenzhen Institute of Synthetic Biology Scientific Research Program [JCHZ20200003]
- Shenzhen Key Laboratory for the Intelligent Microbial Manufacturing of Medicines
Upcycling carbon dioxide into value-added products is a promising solution to environmental issues and achieving a circular economy. This study presents a hybrid electro-biosystem that efficiently converts CO2 to glucose and can be extended to produce other products.
Upcycling of carbon dioxide (CO2) into value-added products represents a substantially untapped opportunity to tackle environmental issues and achieve a circular economy. Compared with easily available C-1/C-2 products, nevertheless, efficient and sustainable synthesis of energy-rich long-chain compounds from CO2 still remains a grand challenge. Here we describe a hybrid electro-biosystem, coupling spatially separate CO2 electrolysis with yeast fermentation, that efficiently converts CO2 to glucose with a high yield. We employ a nanostructured copper catalyst that can stably catalyse pure acetic acid production with a solid-electrolyte reactor. We then genetically engineer Saccharomyces cerevisiae to produce glucose in vitro from electrogenerated acetic acid by deleting all defined hexokinase genes and overexpression of heterologous glucose-1-phosphatase. In addition, we showcase that the proposed platform can be easily extended to produce other products like fatty acids using CO2 as the carbon source. These results illuminate the tantalizing possibility of a renewable-electricity-driven manufacturing industry.
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