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Familial Recurrence Patterns in Congenitally Corrected Transposition of the Great Arteries: An International Study

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Genetics of Transposition of Great Arteries: Between Laterality Abnormality and Outflow Tract Defect

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Summary: Transposition of great arteries (TGA) is a complex congenital heart disease with unknown etiology, associated with genetic abnormalities in laterality establishment and heart outflow tract development. Strong evidence of association with certain genes is found in animal models, but genetic anomalies of human orthologues are low, leaving underlying causes unexplored. Pathogenic mechanisms differ between patients with normal organ disposition and isomerism, highlighting the need for further research in this area.

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