期刊
ASIAN JOURNAL OF PSYCHIATRY
卷 70, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ajp.2022.103027
关键词
NMDA receptor; NMDAR encephalitis; Schizophrenia
类别
This article presents a case of a woman diagnosed with schizophrenia without antiNMDAR antibodies after experiencing NMDAR encephalitis. The study suggests that NMDAR dysfunction may be associated with the onset of schizophrenia.
N-methyl-D-aspartate receptor (NMDAR) dysfunction is an attractive hypothesis regarding the etiology of schizophrenia. We present the unprecedented case of a woman diagnosed with schizophrenia without antiNMDAR antibodies after history of NMDAR encephalitis. A first episode of psychosis was antibody-positive and was improved with steroid and immunoglobulin treatment. Second and third episodes were antibodynegative, each about three months postpartum (different pregnancies) and were improved with antipsychotics. Without NMDAR encephalitis-related findings, we diagnosed schizophrenia. After anti-NMDAR encephalitis, NMDAR dysfunction may decrease the threshold for the onset of psychosis. This case provides insight into NMDAR dysfunction on etiology of schizophrenia.
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