期刊
FRONTIERS IN PUBLIC HEALTH
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpubh.2022.896713
关键词
SARS-CoV-2; COVID-19; age-specific vaccination; booster shot strategies; comorbid-group priority vaccination; non-pharmaceutical intervention
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2021R1I1A1A01044426]
- Chungbuk National University
The study emphasizes the importance of age-specific vaccination prioritization strategies for reducing morbidity and mortality caused by COVID-19, considering different age groups and comorbidities. It highlights the need for effective vaccination strategies in living with the pandemic.
Although the primary and secondary vaccination rates in Korea account for over 75% of the total population, confirmed cases of COVID-19 are dramatically increasing due to immune waning and the Omicron variant. Therefore, it is urgent to evaluate the effectiveness of booster vaccination strategies for living with COVID-19. In this work, we have developed an age-specific mathematical model with eight age groups and included age-specific comorbidities to evaluate the effectiveness of age-specific vaccination prioritization strategies to minimize morbidity and mortality. Furthermore, we have investigated the impacts of age-specific vaccination strategies for different vaccine supplies and non-pharmaceutical intervention levels during two periods: (1) when vaccine supply was insufficient and (2) after the emergence of the omicron variant. During the first period, the best option was to vaccinate the 30-49 year age group and the group with comorbidities to minimize morbidity and mortality, respectively. However, a booster vaccination should prioritize the 30-49 year age group to promote both minimal morbidity and mortality. Critical factors, such as vaccination speed, vaccine efficacy, and non-pharmaceutical interventions (NPIs), should be considered for effective vaccination prioritization as well. Primary, secondary vaccinations, and a booster shot vaccinations require different age prioritization strategies under different vaccination rates, vaccine efficacies, and NPI levels.
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