The quinazoline-2,4(1H,3H)-diones skeleton: A key intermediate in drug synthesis

Quinazoline-2,4(1H,3H)-dione is a major class of N-fused heterocyclic with a wide range of biological functions, including anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities, and other activities, has attracted high attention in organic and medicinal chemistry. As a consequence, all chemists and pharmaceutical chemists should be familiar with the various procedures for producing quinazoline-2,4(1H,3H)-dione. The main purpose of this paper is to provide an overview of the many manufacturing methods for various biological compounds based on the quinazoline-2,4(1H,3H)-dione and 2,4-dichloroquinazoline cores.

Automated summary

Quinazoline-2,4(1H,3H)-dione is a major class of N-fused heterocyclic compound with diverse biological activities, and has attracted considerable attention in organic and medicinal chemistry. This paper provides an overview of the various manufacturing methods for biologically active compounds based on quinazoline-2,4(1H,3H)-dione and 2,4-dichloroquinazoline cores.