期刊
DIAGNOSTICS
卷 12, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics12030760
关键词
two-photon vision; AMD; normal aging; microperimetry; retinal sensitivity
资金
- Klaus Tschira Foundation [00.290.2016]
- National Science Centre [2016/23/B/ST2/00752]
- International Centre for Translational Eye Research within the International Research Agendas Programme of the Foundation for Polish Science - European Union under the European Regional Development Fund [MAB/2019/12]
This study investigates the two-photon vision and sensitivity in patients with age-related macular degeneration (AMD). The results demonstrate a significant impairment of two-photon retinal sensitivity in AMD patients. The study suggests that two-photon vision microperimetry can improve testing accuracy and provide an additional diagnostic parameter for retinal function assessment.
The recently introduced term two-photon vision relates to the visual perception resulting from a simultaneous absorption of two photons by photoreceptors. In this study, we determined two-photon retinal sensitivity in age-related macular degeneration (AMD) and compared it that in normal aging. Microperimetry was performed with visible (white) light and infrared (IR) light, which was perceived as green in the two-photon stimulation. In total, 45 subjects were included with one (better) eye studied. Furthermore, best-corrected visual acuity (VA) and ocular straylight were assessed. AMD resulted in decreased median (interquartile range) logMAR VA, i.e., 0.15 (0.05; 0.24), which in normal eyes was -0.02 (-0.06; 0.02). The two groups showed comparable straylight levels. Sensitivity to IR light was significantly lower in the AMD group (p < 0.001): 8.3 (7.4, 9.3) dB than in controls 10.7 (9.7, 11.2) dB. AMD also significantly affected visible light sensitivity (p < 0.001): 14.0 (11.0; 15.5) dB vs. 18.0 (16.3; 18.9) dB. Notably, the two-photon approach yielded a lower data spread. In conclusion, AMD considerably impairs retinal sensitivity measured in the single- and two-photon realm. However, two-photon-vision microperimetry may improve the testing accuracy and offer an additional diagnostic parameter (beyond VA measurements) for retinal function assessment.
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