4.6 Article

Changes in T2 Relaxation Time Mapping of Intervertebral Discs Adjacent to Vertebrae after Kyphoplasty Correlate with the Physical Clinical Outcome of Patients

期刊

DIAGNOSTICS
卷 12, 期 3, 页码 -

出版社

MDPI
DOI: 10.3390/diagnostics12030605

关键词

intervertebral disc; MRI; T2 mapping; kyphoplasty; clinical outcome

资金

  1. Emerging Fields Initiative (EFI) of the FAU
  2. STAEDTLER Stiftung [EFI_Verbund_Med_05_MIRACLE]
  3. Interdisciplinary Center for Clinical Research (IZKF) at the University Hospital of the University of Erlangen-Nurnberg (FAU) [ELAN P005]
  4. Else Kroner-Memorial Scholarship [2019_EKMS.27]

向作者/读者索取更多资源

In this study, quantitative MRI techniques were used to assess the relationship between tissue changes in intervertebral discs and clinical outcomes following kyphoplasty for vertebral fractures. The results showed that lower T2 values in adjacent discs were associated with poorer physical outcomes, indicating potential for using quantitative T2 mapping as a tool for evaluating tissue degeneration and its impact on patient quality of life post-kyphoplasty.
(1) Background: To assess whether clinical outcomes correlate with tissue changes in the intervertebral discs (IVDs) after kyphoplasty as treatment for vertebral fractures, quantitative MRI was applied. (2) Methods: Quantitative T2 mapping acquired in a 3 T MRI scanner of the thoracolumbar spine was performed in 20 patients two years after kyphoplasty. The IVDs adjacent and nonadjacent to the treated vertebrae were divided into six regions of interest (ROI), which were further categorised into inner (ROI 2-5) and outer (ROI 1 and 6) parts of the IVDs, and the T2 values were analysed. T2 values of adjacent discs were correlated with the items of questionnaires evaluating the clinical outcome (i.e., 36-Item Short Form Survey). (3) Results: Lower T2 values in adjacent IVDs correlated with poorer physical outcome two years after kyphoplasty. The inner part of the IVDs adjacent to treated vertebrae showed statistically significant lower T2 values in segments L2 /L3 and L3/L4 compared to nonadjacent ones. Patients with lower T2 values showed more pain and physical limitations in everyday life. (4) Conclusions: Quantitative T2 mapping can detect IVD degeneration in patients after kyphoplasty and correlates with the physical outcome. This technique could help to gain better insights into alterations in tissue composition following kyphoplasty and the consequences for the patients' quality of life.

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