期刊
ACS OMEGA
卷 7, 期 23, 页码 20006-20019出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.2c01807
关键词
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资金
- Research and Innovation Seed Funding Program (RISF) at NC State University
- Kenan Institute
- NCSU Laboratory Research Equipment Program (LREP)
- National Science Foundation [CCSS1846911]
- American Heart Association [18TPA34230031]
- Wilson College of Textiles
- Department of Textile Engineering, Chemistry, and Science
- Provost's Fellowship at NC State University
This study presents two novel methods, sandwich (sCNT) and dual deposition (DD CNT), for incorporating carbon nanotubes (CNTs) into electrospun polycaprolactone (PCL) and gelatin scaffolds. The inclusion of CNTs significantly increased the scaffolds' conductivity, fiber diameter, pore size, hydrophobicity, Young's modulus, and failure load. Additionally, the CNT-incorporated scaffolds showed high cytocompatibility, making them potential candidates for cardiac and neural tissue engineering.
Carbon nanotubes (CNTs) are known for their excellent conductive properties. Here, we present two novel methods, sandwich (sCNT) and dual deposition (DD CNT), for incorporating CNTs into electrospun polycaprolactone (PCL) and gelatin scaffolds to increase their conductance. Based on CNT percentage, the DD CNT scaffolds contain significantly higher quantities of CNTs than the sCNT scaffolds. The inclusion of CNTs increased the electrical conductance of scaffolds from 0.0 +/- 0.00 kS (non-CNT) to 0.54 +/- 0.10 kS (sCNT) and 5.22 +/- 0.49 kS (DD CNT) when measured parallel to CNT arrays and to 0.25 +/- 0.003 kS (sCNT) and 2.85 +/- 1.12 (DD CNT) when measured orthogonally to CNT arrays. The inclusion of CNTs increased fiber diameter and pore size, promoting cellular migration into the scaffolds. CNT inclusion also decreased the degradation rate and increased hydrophobicity of scaffolds. Additionally, CNT inclusion increased Young's modulus and failure load of scaffolds, increasing their mechanical robustness. Murine fibroblasts were maintained on the scaffolds for 30 days, demonstrating high cytocompatibility. The increased conductivity and high cytocompatibility of the CNT-incorporated scaffolds make them appropriate candidates for future use in cardiac and neural tissue engineering.
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