期刊
PLANTS-BASEL
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/plants11101377
关键词
Parkia biglobosa; Detarium microcarpum; Vitellaria paradoxa; Sclerocarya birrea; polyphenols; anti-inflammatory; anti-nociceptive
资金
- Francophony University Agency
The present study aimed to investigate the polyphenolic profile and anti-inflammatory and anti-nociceptive activities of four traditionally used medicinal plants from Burkina Faso. The results showed that these plants contained high levels of phenolic compounds and demonstrated significant inhibitory effects on inflammation and pain.
The aim of the present study was to investigate the polyphenolic profile and the anti-inflammatory and anti-nociceptive activities of four traditionally used medicinal plants from Burkina Faso: Parkia biglobosa, Detarium microcarpum, Vitellaria paradoxa and Sclerocarya birrea. The analysis of the main phenolic compounds was performed by the HPLC-UV-MS method. The anti-inflammatory effect of the aqueous bark extracts was investigated by the lambda-carrageenan-induced rat paw edema test. The anti-nociceptive activity was evaluated by the Randall-Selitto test under inflammatory conditions. Seven phenolic acids (gallic, protocatechuic, gentisic, vanillic, p-coumaric, ferulic, and syringic acids), and three flavonoids (catechin, epicatechin, and quercitrin) were identified in the plant samples. High contents of gallic acid were determined in the D. microcarpum, P. biglobosa and S. birrea extracts (190-300 mg/100 g), and V paradoxa extract was the richest in epicatechin (173.86 mg/100 g). The lambda-carrageenan-induced inflammation was significantly reduced (p < 0.001) by the P. biglobosa and D. microcarpum extracts (400 mg/kg p.o.). Under the inflammatory conditions, a significant anti-nociceptive activity (p < 0.001) was obtained after 2-3 h from the induction of inflammation. The effects of the tested extracts could be related to the presence of polyphenols and could be useful in the management of certain inflammatory diseases.
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