期刊
PLANTS-BASEL
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/plants11060785
关键词
lemon verbena; plant extracts; traditional medicine; antioxidant; antiproliferation
资金
- Applied Science Private University, Amman, Jordan
This study evaluated the antioxidant and anti-proliferative effects of Aloysia citrodora. The ethyl acetate extract showed significant antiproliferative efficacy, while the ethanol extract exhibited the strongest radical scavenging effect.
Aloysia citrodora (Verbenaceae) is traditionally used to treat various diseases, including bronchitis, insomnia, anxiety, digestive, and heart problems. In this study, this plant's antioxidant and anti-proliferation effects were evaluated. In addition to volatiles extraction, different solvent extracts were prepared. The GC-MS, LC-MS analysis and the Foline-Ciocalteu (F-C) method were used to investigate the phytochemical components of the plant. MTT assay was used to measure the antiproliferative ability for each extract. Antioxidant activity was determined using the 2,2-diphenylpicrylhydrazyl (DPPH) assay. In in vivo anti-proliferation experiments, Balb/C mice were inoculated with tumor cells and IP-injected with ethyl acetate extract of A. citrodora. After treatment, a significant reduction in tumor size (57.97%) and undetected tumors (44.44%) were obtained in treated mice, demonstrating the antiproliferative efficacy of the ethyl acetate extract. Besides, ethanol extract revealed the most potent radical scavenging effect. The findings of this study displayed that A. citrodora has promising cytotoxic and antioxidant activities. Still, further testing is required to investigate the extract's chemical composition to understand its mechanisms of action.
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