Prediction of co-metabolic degradation of bisphenol A and phenol by kinetic modeling

In this work, a model was proposed to describe the ability of Ralstonia eutropha for co-metabolic transformation kinetic of bisphenol A (BPA) as a non-growth substrate in the absence or presence of phenol as a growth substrate. The effects of cell growth, loss of transformation activity, endogenous cell decay, self-inhibition of BPA, loss of transformation activity, and competitive inhibition between BPA and phenol were included in the proposed model. The model then was validated by comparing the predicated and the experimental data. To evaluate the model predictions under different combinations of phenol/BPA concentrations, the kinetic parameters were individually determined. Therefore, BPA transformation and phenol utilization were predicted successfully by the model for a defined range of concentrations of phenol (15-100 mg.l(-1)) and BPA (5-40 mg.l(-1)). (C) 2022 The Author(s). Published by Elsevier B.V.

Automated summary

A model was proposed to describe the co-metabolic transformation kinetics of bisphenol A (BPA) by Ralstonia eutropha as a non-growth substrate in the presence or absence of phenol as a growth substrate. The model considered various factors and was validated against experimental data. The results showed that the model successfully predicted the transformation of BPA and utilization of phenol within a certain concentration range.