期刊
ANTIBIOTICS-BASEL
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11030417
关键词
rivers; one health; E; coli; fluoroquinolones; antimicrobial resistance; AMR
This study found a positive correlation between the national median concentration of ciprofloxacin in rivers and fluoroquinolone resistance in Escherichia coli.
Background: Extremely low concentrations of ciprofloxacin may select for antimicrobial resistance. A recent global survey found that ciprofloxacin concentrations exceeded safe levels at 64 sites. In this study, I assessed if national median ciprofloxacin concentrations in rivers were associated with fluoroquinolone resistance in Escherichia coli. Methods: Spearman's regression was used to assess the country-level association between the national prevalence of fluoroquinolone resistance in E. coli and the median ciprofloxacin concentration in the country's rivers. Results: The prevalence of fluoroquinolone resistance in E. coli was positively correlated with the concentration of ciprofloxacin in rivers (rho = 0.36; p = 0.011; n = 48). Discussion: Steps to reducing the concentrations of fluoroquinolones in rivers may help prevent the emergence of resistance in E. coli and other bacterial species.
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