期刊
ANTIBIOTICS-BASEL
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11040491
关键词
phosphonium ionic liquids; antibacterial; Acinetobacter baumannii; antioxidants; OCHEM; QSAR
资金
- German Federal Ministry for Education and Research (BMBF) [01DK20018]
This study utilized a previously developed model to evaluate the antibacterial activity of phosphonium ionic liquids, and newly developed models to assess their antioxidant potential. Experimental results confirmed the activity of phosphonium ionic liquids against Acinetobacter baumannii and their significant antioxidant properties.
A previously developed model to predict antibacterial activity of ionic liquids against a resistant A. baumannii strain was used to assess activity of phosphonium ionic liquids. Their antioxidant potential was additionally evaluated with newly developed models, which were based on public data. The accuracy of the models was rigorously evaluated using cross-validation as well as test set prediction. Six alkyl triphenylphosphonium and alkyl tributylphosphonium bromides with the C-8, C-10, and C-12 alkyl chain length were synthesized and tested in vitro. Experimental studies confirmed their activity against A. baumannii as well as showed pronounced antioxidant properties. These results suggest that phosphonium ionic liquids could be promising lead structures against A. baumannii.
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