期刊
ANTIBIOTICS-BASEL
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11040482
关键词
Dysphania ambrosioides; antioxidant activity; antimicrobial activity; essential oils; computational study; molecular docking
资金
- Conseil Departemental d'Eure et Loir
This study determined the phytochemical composition, antioxidant, and antibacterial activities of essential oils extracted from D. ambrosioides in Eastern Morocco. The results revealed moderate antioxidant and broad-spectrum antibacterial properties.
Dysphania ambrosioides (L.) Mosyakin and Clemants, also known as Mexican tea, and locally known as Mkhinza, is a polymorphic annual and perennial herb, and it is widely used in folk medicine to treat a broad range of illnesses in Morocco. The aim of this study was to determine the phytochemical content and the antioxidant and the antibacterial properties of essential oils isolated from D. ambrosioides aerial components, growing in Eastern Morocco (Figuig). Hydrodistillation was used to separate D. ambrosioides essential oils, and the abundance of each phytocompound was determined by using Gas Chromatography coupled with Mass Spectrometry (GC-MS). In vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and inhibition of beta-carotene/linoleic acid bleaching assays were used to determine D. ambrosioides essential oils' antioxidant activity. The findings revealed relative antioxidative power and modest radical scavenging. The antibacterial activity of the essential oils was broad-spectrum, with Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis as the most susceptible strains tested. To elucidate the physicochemical nature, drug-likeness, and the antioxidant and antibacterial action of the identified phytocomponents, computational techniques, such as ADMET analysis, and molecular docking were used.
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