Summary: Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy affecting the kidneys, while atypical HUS involves genetic or acquired dysregulation of the complement alternative pathway. The patient in the case experienced symptoms after vaccination with ChAdOx1 nCoV-19, leading to a clinical presentation of aHUS.

NEPHRON (2022)

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Review Urology & Nephrology

Thrombotic microangiopathy in aHUS and beyond: clinical clues from complement genetics

Fadi Fakhouri et al.

Summary: Studies of complement genetics have led to specific treatments for aHUS, raised questions about systematic testing in typical and secondary HUS, and highlighted complexities in interpreting results for malignant hypertension-associated TMA.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Microbiology

Renal Thrombotic Microangiopathy in Concurrent COVID-19 Vaccination and Infection

Marco De Fabritiis et al.

Summary: This case report describes a 35-year-old male who developed nephrotic proteinuria and microhematuria following the first dose of BNT162b2 COVID-19 vaccine and COVID-19 diagnosis. After high-dose steroid treatment, complete remission of proteinuria was achieved in a few weeks. The association of renal thrombotic microangiopathy with COVID-19 has been described previously, but the correlation with COVID-19 vaccine is a novel finding.

PATHOGENS (2021)

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First case of atypical haemolytic uraemic syndrome following COVID-19 vaccination with BNT162b2

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Thrombotic thrombocytopenic purpura temporally associated with BNT162b2 vaccination in an adolescent successfully treated with caplacizumab

Atypical Hemolytic Uremic Syndrome after ChAdOx1 nCoV-19 Vaccination in a Patient with Homozygous CFHR3/CFHR1 Gene Deletion

Thrombotic microangiopathy in aHUS and beyond: clinical clues from complement genetics

Renal Thrombotic Microangiopathy in Concurrent COVID-19 Vaccination and Infection

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