期刊
FOODS
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/foods11111591
关键词
fish hydrolysate; proteomics; acute mild stress; mouse; hippocampus; mitochondria; neuronal network
资金
- Biogenouest, Infrastructures en Biologie Sante et Agronomie (IBiSA)
- Conseil Regional de Bretagne
The supplementation of fish hydrolysates has shown to prevent stress-induced dysregulation of proteins, indicating its potential as an innovative strategy for stress management.
Over the past several decades, stress has dramatically increased in occidental societies. The use of natural resources, such as fish hydrolysates, may be an attractive strategy to improve stress management. Our previous study demonstrated the anxiolytic effects of fish hydrolysate supplementation in mice exposed to acute mild stress by limiting stress-induced corticosterone release and modulating the expression of a number of stress-responsive genes. Here, we explore hippocampal protein modulation induced by fish hydrolysate supplementation in mice submitted to acute mild stress, with the aim of better elucidating the underlying mechanisms. Hippocampi from the same cohort of Balb/c mice supplemented with fish hydrolysate (300 mg.kg(-1) body weight) or vehicle daily for seven days before being submitted or not to an acute mild stress protocol (four groups, n = 8/group) were subjected to label-free quantitative proteomics analysis combined with gene ontology data mining. Our results show that fish hydrolysate supplementation prevented the observed stress-induced dysregulation of proteins relative to mitochondrial pathways and the neuronal network. These findings suggest that fish hydrolysate represents an innovative strategy to prevent the adverse effects of stress and participate in stress management.
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