Role of Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation

Obesity is a disease characterized by an inflammatory process in the adipose tissue due to diverse infiltrated immune cells, an increased secretion of proinflammatory molecules, and a decreased secretion of anti-inflammatory molecules. On the other hand, obesity increases the risk of several diseases, such as cardiovascular diseases, diabetes, and cancer. Their treatment is based on nutritional and pharmacological strategies. However, natural products are currently implemented as complementary and alternative medicine (CAM). Polyphenols and fiber are naturally compounds with potential action to reduce inflammation through several pathways and play an important role in the prevention and treatment of obesity, as well as in other non-communicable diseases. Hence, this review focuses on the recent evidence of the molecular mechanisms of polyphenols and dietary fiber, from Scopus, Science Direct, and PubMed, among others, by using key words and based on recent in vitro and in vivo studies.

Automated summary

Obesity is a disease characterized by inflammation in adipose tissue, caused by immune cell infiltration, increased proinflammatory molecule secretion, and decreased anti-inflammatory molecule secretion. It also increases the risk of cardiovascular diseases, diabetes, and cancer. Natural products such as polyphenols and fiber have potential anti-inflammatory effects and play an important role in the prevention and treatment of obesity and other non-communicable diseases.