期刊
NATURE AND SCIENCE OF SLEEP
卷 14, 期 -, 页码 483-492出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NSS.S357848
关键词
inflammatory diet; sleep quality; cardiovascular disease; NHANES; mediation
资金
- National Natural Science Foundation of China [81973129]
This study investigates the relationship between sleep quality, dietary inflammation, and cardiovascular disease (CVD) risk. It finds that poor sleep quality is associated with a higher 10-year CVD risk, and this association is partially mediated by dietary inflammation. Controlling the intake of inflammatory foods can reduce the risk of CVD, especially for individuals with sleep disorders.
Objective: People with poor sleep quality have higher risk of cardiovascular disease (CVD), and one potential mechanism of CVD is chronic inflammation. The aim of this study was to investigate the role of dietary inflammation in the relationship between sleep quality and CVD risk. Methods: This study involved 5594 participants from the National Health and Nutrition Examination Survey (NHANES) in 2005- 2008. Sleep quality, dietary inflammation, and 10-year CVD risk were evaluated via the Pittsburgh Sleep Quality Index (PSQI), the Energy-adjusted Dietary Inflammatory Index (E-DII), and the Framingham Risk Score (FRS), respectively. We used generalized additive model (GAM) and mediation analysis to investigate the relationship among sleep quality, 10-year CVD risk, and E-DII. Results: PSQI had a non-linear relationship with 10-year CVD risk (P < 0.001). Meanwhile, among the participants with poor sleep quality, PSQI was positively associated with increased 10-year CVD risk (P < 0.001) and E-DII (P < 0.001). Furthermore, the association between sleep quality and CVD risk was partially mediated by E-DII, and the mediated proportion was 14.6%, and the mediating effect of E-DII varied in different gender and age groups. However, in the subjects with good sleep quality, the association among PSQI, E-DII, and 10-year CVD risk was not existed. Conclusion: Ten-year CVD risk could be reduced by controlling the intake of inflammatory food, especially for whom with sleep disorders. In general, the reduction of inflammatory diet could weaken the effect of sleep disorders on the CVD risk.
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