4.7 Article

The Lipid-Lowering Effect of Dietary Taurine in Orange-Spotted Groupers (Epinephelus coioides) Involves Both Bile Acids and Lipid Metabolism

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FRONTIERS IN MARINE SCIENCE
卷 9, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fmars.2022.859428

关键词

taurine; high lipid diet; bile acid profile; lipid metabolism; liver lipid deposition; Epinephelus coioides

资金

  1. National Natural Science Foundation of China [31772861, 31372546]
  2. Science and Technology Project of Fujian Province of China [2020N0012]

向作者/读者索取更多资源

This study suggests that dietary taurine supplementation can alleviate liver lipid deposition in juvenile orange-spotted grouper by accelerating lipid absorption and inhibiting lipogenesis.
An 8-week feeding trial was conducted to investigate how dietary taurine supplementation attenuates the lipid deposition induced by dietary high lipid in juvenile orange-spotted grouper (Epinephelus coioides). Three isonitrogenous (47% crude protein) semipurified diets were formulated to contain two levels of lipid and termed as 10% lipid diet, 15% lipid diet, and 15% lipid with 1% taurine (namely, diet 10L, diet 15L, and diet 15L + T, respectively). Groupers fed diet 15L + T showed higher weight gain and feed efficiency compared with diet 15L. Groupers fed diet 15L showed higher liver lipid contents, plasma total cholesterol (TC), and leptin contents vs. those fed diet 10L. Diet 15L + T decreased hepatosomatic index, liver lipid content, and plasma TC and adiponectin contents, and increased liver 3-hydroxy-3-methy1 glutary1 coenzyme A reductase content compared with diet 15L. Fish fed diet 15L had higher contents of chenodeoxycholic acid, deoxycholic acid, and lithocholic acid, and lower contents of glycodeoxycholic acid (GDCA), glycolithocholic acid, glycoursodeoxycholic acid, taurodeoxycholic acid (TDCA), and beta-, gamma-, and omega-muricholic acid (MCA) when compared with fish fed diet 10L. Diet 15L + T downregulated the contents of glycocholic acid, glycochenodeoxycholic acid, taurohyodeoxycholic acid, tauromuricholic acid, TDCA, ursodeoxycholic acid, GDCA, and beta-MCA vs. diet 15L. Diet 15L upregulated expression of peroxisome proliferator-activated receptor alpha (ppar alpha) gene but downregulated expression of acyl-CoA carboxylase (acc), fatty acid synthase (fas), and glucose-6-phosphate dehydrogenase (g6pd) genes in comparison with diet 10L. The gene expression level of fas and 6pgd was downregulated and the ppar alpha gene expression level was upregulated in fish fed diet 15L + T compared with those in fish fed diet 15L. Overall, this study indicated that dietary taurine supplementation can attenuate the liver lipid deposition of groupers caused by feeding 15% lipid through accelerating lipid absorption of taurine-conjugated bile acids and fatty acid beta-oxidation and inhibiting lipogenesis.

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