期刊
METABOLITES
卷 12, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/metabo12060488
关键词
multi-omics; metabolomics; proteomics; transcriptomics; genomics; prostate cancer
资金
- NIH NIGMS [P20GM121327]
- NIH NCI [R03 R03CA256230]
- University of Kentucky Markey Cancer Center
This review focuses on the integration of metabolomics with multi-omics platforms in prostate cancer research, specifically highlighting the metabolomic profile of prostate cancer. The authors aim to provide researchers in the field with a comprehensive knowledge base in prostate cancer metabolomics and offer perspectives on overcoming limitations of the tool for future point-of-care applications.
Our understanding of prostate cancer (PCa) has shifted from solely caused by a few genetic aberrations to a combination of complex biochemical dysregulations with the prostate metabolome at its core. The role of metabolomics in analyzing the pathophysiology of PCa is indispensable. However, to fully elucidate real-time complex dysregulation in prostate cells, an integrated approach based on metabolomics and other omics is warranted. Individually, genomics, transcriptomics, and proteomics are robust, but they are not enough to achieve a holistic view of PCa tumorigenesis. This review is the first of its kind to focus solely on the integration of metabolomics with multi-omic platforms in PCa research, including a detailed emphasis on the metabolomic profile of PCa. The authors intend to provide researchers in the field with a comprehensive knowledge base in PCa metabolomics and offer perspectives on overcoming limitations of the tool to guide future point-of-care applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据