期刊
METABOLITES
卷 12, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/metabo12050471
关键词
Bos taurus indicus; differential co-expression; RIF; DH; PCIT; WGCNA
资金
- Sao Paulo Research Foundation-FAPESP [2011/2141-0, 2017/10630-2, 2018/20026-8]
This study identified potential regulatory genes of the essential fatty acid profile in Nellore cattle finished in feedlot through differentially expressed genes analysis and two co-expression methodologies. Functional enrichment analysis was also conducted to provide insights into the genetic mechanisms underlying the beef EFA profile.
Beef is a source of essential fatty acids (EFA), linoleic (LA) and alpha-linolenic (ALA) acids, which protect against inflammatory and cardiovascular diseases in humans. However, the intramuscular EFA profile in cattle is a complex and polygenic trait. Thus, this study aimed to identify potential regulatory genes of the essential fatty acid profile in Longissimus thoracis of Nellore cattle finished in feedlot. Forty-four young bulls clustered in four groups of fifteen animals with extreme values for each FA were evaluated through differentially expressed genes (DEG) analysis and two co-expression methodologies (WGCNA and PCIT). We highlight the ECHS1, IVD, ASB5, and ERLIN1 genes and the TF NFIA, indicated in both FA. Moreover, we associate the NFYA, NFYB, PPARG, FASN, and FADS2 genes with LA, and the RORA and ELOVL5 genes with ALA. Furthermore, the functional enrichment analysis points out several terms related to FA metabolism. These findings contribute to our understanding of the genetic mechanisms underlying the beef EFA profile in Nellore cattle finished in feedlot.
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