Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis

Article Cardiac & Cardiovascular Systems

Benefits of Icosapent Ethyl Across the Range of Kidney Function in Patients With Established Cardiovascular Disease or Diabetes: REDUCE-IT RENAL

Arjun Majithia et al.

Summary: In the REDUCE-IT trial, icosapent ethyl reduced fatal and nonfatal ischemic events across a broad range of baseline eGFR categories.

CIRCULATION (2021)

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Article Endocrinology & Metabolism

The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis

Pablo Ranea-Robles et al.

Summary: This study investigated the role of peroxisomal transporter ABCD3 in hepatic lipid homeostasis and DCA metabolism using a CRISPR-Cas9 generated Abcd3 KO mouse model. The findings suggest that dysfunction of ABCD3 leads to DCAs being metabolized by mitochondrial fatty acid beta-oxidation, highlighting the importance of metabolic compartmentalization and communication between peroxisomes and mitochondria. The study provides valuable insights into the consequences of peroxisomal dysfunction for the liver.

JOURNAL OF INHERITED METABOLIC DISEASE (2021)

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Article Nutrition & Dietetics

Analysis of Serum Fatty Acids Profile in Kidney Transplant Recipients

Adriana Mika et al.

Summary: This study found significant abnormalities in the fatty acid profile of kidney transplant recipients, especially in terms of branched chain fatty acids, monounsaturated fatty acids, and n-6 polyunsaturated fatty acids. These abnormalities may contribute to cardiovascular risk in this patient population.

NUTRIENTS (2021)

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Article Hematology

Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality

Tiffany Thomas et al.

Summary: The study found that fatty acid desaturases are present and active in mature RBCs, and their activity is sensitive to oxidant stress, storage duration, and alterations of the pyruvate/lactate ratio.

TRANSFUSION (2021)

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Review Biochemistry & Molecular Biology

Effects of Dietary n-3 and n-6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

Kamila P. Liput et al.

Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nutrition & Dietetics

Heart Rate Variability and Long Chain n-3 Polyunsaturated Fatty Acids in Chronic Kidney Disease Patients on Haemodialysis: A Cross-Sectional Pilot Study

Ana M. Pinto et al.

Summary: This study found that in hemodialysis patients, heart rate variability is associated with LC n-3 PUFA levels. Higher EPA/DHA ratio was correlated with lower HRV parameters, suggesting LC n-3 PUFA may impact arrhythmic risk and cardiac autonomic function.

NUTRIENTS (2021)

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Review Cardiac & Cardiovascular Systems

A Fishy Topic: VITAL, REDUCE-IT, STRENGTH, and Beyond: Putting Omega-3 Fatty Acids into Practice in 2021

Tahreem Iqbal et al.

Summary: Recent studies comparing the addition of omega-3 fatty acids, specifically EPA and DHA, to standard of care therapy for cardiovascular disease have shown that purified EPA may provide more significant benefits in reducing CVD risk than the combination of EPA and DHA. Experimental data suggests that EPA has antioxidant, anti-inflammatory, and membrane stabilizing properties that may enhance vascular function and decrease CVD risk compared to DHA.

CURRENT CARDIOLOGY REPORTS (2021)

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Review Biochemistry & Molecular Biology

A global perspective on the crosstalk between saturated fatty acids and Toll-like receptor 4 in the etiology of inflammation and insulin resistance

Bin Li et al.

PROGRESS IN LIPID RESEARCH (2020)

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Article Physiology

Effects of hemodialysis on blood fatty acids

Benjamin Gollasch et al.

PHYSIOLOGICAL REPORTS (2020)

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Review Medicine, General & Internal

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease

Asmaa S. Abdelhamid et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2020)

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Article Urology & Nephrology

US Renal Data System 2018 Annual Data Report: Epidemiology of Kidney Disease in the United States

Rajiv Saran et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2019)

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Article Physiology

Maximal exercise and erythrocyte epoxy fatty acids: a lipidomics study

Benjamin Gollasch et al.

PHYSIOLOGICAL REPORTS (2019)

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Article Nutrition & Dietetics

Altered Serum n-6 Polyunsaturated Fatty Acid Profile and Risks of Mortality and Cardiovascular Events in a Cohort of Hemodialysis Patients

Yukinobu Kuwamura et al.

JOURNAL OF RENAL NUTRITION (2018)

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Review Nutrition & Dietetics

Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review

Ban-Hock Khor et al.

NUTRIENTS (2018)

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Article Medicine, General & Internal

A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk

Dominik D. Alexander et al.

MAYO CLINIC PROCEEDINGS (2017)

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Article Transplantation

Prevalence of chronic kidney disease in a representative sample of the Polish population: results of the NATPOL 2011 survey

Lukasz Zdrojewski et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2016)

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Review Biochemistry & Molecular Biology

Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults

Ken D. Stark et al.

PROGRESS IN LIPID RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Red blood cell PUFAs reflect the phospholipid PUFA composition of major organs

Jenifer I. Fenton et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2016)

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Article Biochemistry & Molecular Biology

Plasma and erythrocyte membrane phospholipids and fatty acids in Italian general population and hemodialysis patients

Mariarita Dessi et al.

LIPIDS IN HEALTH AND DISEASE (2014)

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Article Nutrition & Dietetics

Serum phospholipid monounsaturated fatty acid composition and Δ-9-desaturase activity are associated with early alteration of fasting glycemic status

Jae Sun Cho et al.

NUTRITION RESEARCH (2014)

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Article Endocrinology & Metabolism

Erythrocyte n-3 Polyunsaturated Fatty Acids and the Risk of Type 2 Diabetes in Koreans: A Case-Control Study

Sunyoung Jo et al.

ANNALS OF NUTRITION AND METABOLISM (2013)

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Article Nutrition & Dietetics

Fatty Acid–Regulated Transcription Factors in the Liver

Donald B. Jump et al.

Annual Review of Nutrition (2013)

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Review Genetics & Heredity

Soluble epoxide hydrolase: Gene structure, expression and deletion

Todd R. Harris et al.

GENE (2013)

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Article Biochemistry & Molecular Biology

Increased Lipogenesis and Stearate Accelerate Vascular Calcification in Calcifying Vascular Cells

Tabitha C. Ting et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Article Biochemistry & Molecular Biology

Lipidomics reveals a remarkable diversity of lipids in human plasma

Oswald Quehenberger et al.

JOURNAL OF LIPID RESEARCH (2010)

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Article Pharmacology & Pharmacy

Arteriovenous Differences in NO2- Kinetics in Anesthetized Rabbits

Takaharu Ishibashi et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2009)

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Article Gastroenterology & Hepatology

The Plasma Lipidomic Signature of Nonalcoholic Steatohepatitis

Puneet Puri et al.

HEPATOLOGY (2009)

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Article Peripheral Vascular Disease

Intakes of Long-Chain Omega-3 Fatty Acid Associated with Reduced Risk for Death from Coronary Heart Disease in Healthy Adults

William S. Harris et al.

CURRENT ATHEROSCLEROSIS REPORTS (2008)

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Article Nutrition & Dietetics

Dietary-induced changes in fatty acid composition of human plasma, platelet, and erythrocyte lipids follow a similar time course

CM Skeaff et al.

JOURNAL OF NUTRITION (2006)

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Review Urology & Nephrology

Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients

K Kalantar-Zadeh et al.

KIDNEY INTERNATIONAL (2003)

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Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis

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