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Article
Microbiology
Lisvaneth Medina et al.
Summary: Research has found that Trypanosoma cruzi infection induces cellular proliferation, differentiation, and apoptotic cell death in the trophoblast, which are regulated by microRNAs miR-512-3p and miR-515-5p. Parasite-modulated microRNAs could potentially be used as biomarkers, prognostic, and therapeutic tools for congenital Chagas disease.
Article
Microbiology
Gabriela Maira Pereira de Assis et al.
Summary: The study found that the nervous form of Chagas disease is associated with brain lesions and behavioral changes, which are affected by the muscarinic acetylcholine receptor (mAChR) activation or blockade. Blocking the mAChR was found to promote infection evolution and brain damage, while activation helped maintain brain tissue integrity.
Article
Microbiology
Sofia Ocana-Mayorga et al.
Summary: Understanding the blood meal patterns of disease vectors is crucial in developing strategies to decrease human-vector contact. In Ecuador, limited data on Chagas disease infection are available, but active transmission has been demonstrated in endemic areas. This study found that humans are the main food source for triatomines, although birds, particularly chickens, might also play a significant role in maintaining these vectors in certain areas.
Review
Microbiology
German J. Medina-Rincon et al.
Summary: Chagas disease presents as disabling and life-threatening conditions mainly affecting the cardiovascular and gastrointestinal systems. Despite progress in understanding the molecular mechanisms underlying infection and host-parasite interactions, prompt diagnosis and treatment remain a challenge in developing countries and those where the disease is not considered endemic.
Review
Microbiology
Natalia Vacani-Martins et al.
Summary: Chagas disease, caused by the protozoan Trypanosoma cruzi, was described over a century ago by Dr. Carlos Chagas in Brazil. Liver involvement, particularly hepatomegaly, is a common clinical sign and is more pronounced in cases of oral infection found in the Amazon region. Despite efforts to understand the mechanisms leading to cardiac and digestive manifestations in chronic patients, the importance of liver involvement and hepatic immune response in disease progression has not received much attention.
Article
Microbiology
Victor D. Carmona-Galindo et al.
Summary: This study evaluates how the physical characteristics of Triatoma dimidiata vary in relation to land use in El Salvador, finding that the color and morphology of T. dimidiata change directly with anthropogenic changes to natural and agricultural environments. The adaptable population of T. dimidiata is primed to respond to environmental change, suggesting that mitigation efforts for Chagas disease should consider the relationships between anthropogenic land use and T. dimidiata morphology to understand the impact on disease transmission patterns.
