期刊
PATHOGENS
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/pathogens11040398
关键词
mast cells; Leishmania mexicana; sand fly salivary proteins; sexual hormones
类别
资金
- UNAM-PAPIIT [IG201221]
- CONACYT [6682]
The presence of male sex hormones modulates the mast-cell response to Leishmania infections and salivary proteins of the sand fly vector, inducing an intense inflammatory response. Their absence in orchiectomized mice results in a delayed inflammatory response, enabling better control of the infection and slower disease progression.
Mast cells (MCs) play a crucial role during Leishmania infections, which is transmitted through the bite of an infected sand fly that injects saliva together with the parasite. Sand fly saliva is a complex fluid that modulates the host immune response. In addition, hormonal factors modulate the host immune response and alter susceptibility to infections. Thus, to assess the impact of male sex hormones on the mast-cell (MC) response to Leishmania infections, we orchiectomized male mice, infected them with the parasite in the presence of sand fly salivary proteins, and analyzed the inflammatory response of MCs. Our results showed that the MC response to the parasite and vector salivary proteins differed between orchiectomized and sham-operated mice. In orchiectomized mice, MC showed a retarded activation pattern, associated with slower degranulation and weaker TNF-alpha, histamine, and tryptase staining in response to the infection with Leishmania mexicana combined with vector-salivary proteins, as compared to sham mice. Furthermore, neutrophil infiltration was slower in orchiectomized mice, and numbers of infected macrophages and lesion sizes were smaller. Our results show that, during Leishmania infection, male sex hormones modulate the mast-cell response against the parasite and salivary proteins of the sand fly vector, inducing an intense inflammatory response. Their absence in orchiectomized mice retards the inflammatory response, enabling better control of the infection and slower disease progression.
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