4.6 Article

Nrf2 Modulates the Hybrid Epithelial/Mesenchymal Phenotype and Notch Signaling During Collective Cancer Migration

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Dll4/Notch1 signalling pathway is required in collective invasion of salivary adenoid cystic carcinoma

Ke Wang et al.

Summary: High expression of Dll4 is associated with invasive front of SACC, solid tumor type, high TNM grade, and high metastasis and recurrence rates. Notch1 and Dll4 are positively correlated at the invasive front, with leader cells showing high Dll4 expression and follower cells showing high Notch1 expression in a 3D culture model. Silencing Dll4 reduces migration and invasion of SACC cells, but overexpression of Notch1 can rescue these abilities. Dll4/Notch1 signaling pathway may play a role in collective invasion of SACC and could be a potential target for SACC treatment.

ONCOLOGY REPORTS (2021)

Article Multidisciplinary Sciences

Nrf2 regulates cell motility through RhoA-ROCK1 signalling in non-small-cell lung cancer cells

Eunsun Ko et al.

Summary: Nrf2 is a important regulator of antioxidant and anti-inflammatory enzymes, interacting with Keap1 to affect the transcription of cytoprotective enzymes. The Nrf2/Keap1 pathway may impact cell motility through dysregulation of the RhoA-ROCK1 signaling pathway in non-small cell lung cancer cells.

SCIENTIFIC REPORTS (2021)

Article Medicine, General & Internal

Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology

Satwik Pasani et al.

Summary: Metastasis is still a clinical challenge, with cancer cells exhibiting dynamic movement along the epithelial-hybrid-mesenchymal spectrum and stemness. A mathematical model was developed to explore the nonlinear dynamics of networks regulating E/M plasticity and stemness, revealing that hybrid E/M phenotypes are more likely to acquire stemness. The study also showed that factors stabilizing hybrid E/M phenotypes contribute to the enrichment of stemness, providing insights into tumor initiation mechanisms.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Oncology

The KEAP1-NRF2 System as a Molecular Target of Cancer Treatment

Keiko Taguchi et al.

Summary: The KEAP1-NRF2 system attracts extensive interest in cancer research due to NRF2's dual activity as an oncogene and tumor suppressor. NRF2-addicted cancers exhibit high NRF2 expression and somatic mutations stabilize and accumulate NRF2. These cancers hijack NRF2's cytoprotective roles to survive in harsh microenvironments.

CANCERS (2021)

Article Cell Biology

Intratumoral Heterogeneity Promotes Collective Cancer Invasion through NOTCH1 Variation

Peter Torab et al.

Summary: Cellular and molecular heterogeneity within tumors can enhance invasiveness, although the exact mechanism is not fully understood. Studies have shown that interaction between molecular subtypes within tumors can affect invasiveness, and variation in gene expression can further influence invasiveness.
Article Multidisciplinary Sciences

Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing

Abhijeet P. Deshmukh et al.

Summary: This study identified the complexity of the EMT process by analyzing gene expression profiles during EMT progression. It demonstrated that NOTCH signaling pathway drives TGF-beta-induced EMT, and gene signatures corresponding to intermediate hybrid EMT state are associated with poor patient outcome.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Oncology

A Theoretical Approach to Coupling the Epithelial-Mesenchymal Transition (EMT) to Extracellular Matrix (ECM) Stiffness via LOXL2

Youyuan Deng et al.

Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in cancer progression, with recent studies highlighting its connection to mechanical microenvironment such as extracellular matrix (ECM) stiffness. LOXL2 plays a role in promoting fiber cross-linking in ECM, which leads to increased stiffness and induces EMT. The positive feedback loop formed among EMT, LOXL2, and ECM stiffness can lock cells in a mesenchymal state and impact migrating cancer cells trying to escape the primary tumor.

CANCERS (2021)

Article Oncology

Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states

Kamen P. Simeonov et al.

Summary: This study introduces a new inducible CRISPR-Cas9-based lineage recorder, macsGESTALT, and reveals that the metastatic potential of cells peaks in rare, late-hybrid EMT states, which are relevant to clinical disease progression.

CANCER CELL (2021)

Review Oncology

Decoding leader cells in collective cancer invasion

Samuel A. Vilchez Mercedes et al.

Summary: Collective cancer cell invasion with leader-follower organization is a key mechanism of metastasis, but a consensus definition of leader cell characteristics is lacking. This Perspective outlines a conceptual framework for understanding how leader cells coordinate the invasion process using a multitude of cellular and molecular programmes.

NATURE REVIEWS CANCER (2021)

Article Multidisciplinary Sciences

Context specificity of the EMT transcriptional response

David P. Cook et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Analytical

Three-Dimensional Microtumors for Probing Heterogeneity of Invasive Bladder Cancer

Peter Torab et al.

ANALYTICAL CHEMISTRY (2020)

Article Medicine, Research & Experimental

Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT-1

Fei Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

Article Biochemistry & Molecular Biology

Self-organized multicellular structures from simple cell signaling: a computational model

Nicola Mulberry et al.

PHYSICAL BIOLOGY (2020)

Review Developmental Biology

Mechanisms of Notch signaling: a simple logic deployed in time and space

Domingos Henrique et al.

DEVELOPMENT (2019)

Article Cell Biology

Nrf2 promotes breast cancer cell migration via up-regulation of G6PD/HIF-1α/Notch1 axis

Hong-Sheng Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Multidisciplinary Sciences

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

Cornelia Kroger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Medicine, General & Internal

Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response

Dongya Jia et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Multidisciplinary Sciences

Pericytes enable effective angiogenesis in the presence of proinflammatory signals

Tae-Yun Kang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment

Federico Bocci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

Stability and mean residence times for hybrid epithelial/mesenchymal phenotype

Kuheli Biswas et al.

PHYSICAL BIOLOGY (2019)

Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

Review Oncology

Notch Signaling in the Tumor Microenvironment

Olivier Meurette et al.

CANCER CELL (2018)

Review Oncology

EMT in cancer

Thomas Brabletz et al.

NATURE REVIEWS CANCER (2018)

Article Multidisciplinary Sciences

Numb prevents a complete epithelial-mesenchymal transition by modulating Notch signalling

Federico Bocci et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2017)

Article Chemistry, Analytical

Probing 3D Collective Cancer Invasion Using Double-Stranded Locked Nucleic Acid Biosensors

Zachary S. Dean et al.

ANALYTICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Article Multidisciplinary Sciences

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

Marcelo Boareto et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2016)

Review Cell Biology

Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad

Angelo Sparaneo et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Biochemistry & Molecular Biology

Crosstalk between Nrf2 and Notch signaling

Nobunao Wakabayashi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Multidisciplinary Sciences

Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype

Marcelo Boareto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Oncology

Implications of the hybrid epithelial/mesenchymal phenotype in metastasis

Mohit Kumar Jolly et al.

FRONTIERS IN ONCOLOGY (2015)

Article Cell Biology

Single cell gene expression analysis in injury-induced collective cell migration

Reza Riahi et al.

INTEGRATIVE BIOLOGY (2014)

Article Multidisciplinary Sciences

MicroRNA-based regulation of epithelial-hybridmesenchymal fate determination

Mingyang Lu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Cell Biology

How does cancer cell metabolism affect tumor migration and invasion?

Tianyu Han et al.

CELL ADHESION & MIGRATION (2013)

Article Clinical Neurology

The Role of Nrf2 in Migration and Invasion of Human Glioma Cell U251

Hao Pan et al.

WORLD NEUROSURGERY (2013)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Biochemistry & Molecular Biology

The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells

Simone Brabletz et al.

EMBO JOURNAL (2011)

Article Biochemistry & Molecular Biology

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

Rui Benedito et al.

Review Pharmacology & Pharmacy

Dual roles of Nrf2 in cancer

Alexandria Lau et al.

PHARMACOLOGICAL RESEARCH (2008)