Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naive Subjects

H-1 NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naive subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naive subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.

Automated summary

The H-1 NMR spectra of sera were used to analyze the changes induced by vaccination with Pfizer-BioNTech vaccine in COVID-19-recovered and COVID-19-naive subjects. The results show that vaccination does not significantly affect the metabolome, but causes changes in lipoprotein levels. The effects differ between the recovered and naive subjects, suggesting that prior infection reduces the vaccine's modulation of lipoprotein composition.